PF-04979064 is a potent and selective PI3K / mTOR dual kinase inhibitor with K i s of 0.13 nM and 1.42 nM for PI3Kα and mTOR , respectively.
In Vitro
PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα K i of 0.13 nM, PI3Kγ K i of 0.111 nM, and PI3Kδ K i of 0.122 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T 1/2 =1.85 h, and F%=61% . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
