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Cyclic nucleotide turnover/signalling
PF-06928215 - 98%, high purity , CAS No.2378173-15-8, Inhibitor of Cyclic GMP-AMP synthase

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PF-06928215 - 98%, high purity , CAS No.2378173-15-8, Inhibitor of Cyclic GMP-AMP synthase

Moligand™
≥98%

CAS#: 2378173-15-8
Formula: C₂₀H₂₀N₄O₄
Molecular Weight: 380.4
PubChem CID: 137300622

Item Number

P420009

Grouped product items
SKU	Size	Availability	Price
P420009-1mg	1mg	In stock	$54.90
P420009-5mg	5mg	In stock	$227.90
P420009-10mg	10mg	In stock	$335.90
P420009-25mg	25mg	In stock	$632.90
P420009-50mg	50mg	In stock	$949.90
P420009-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,385.90

View related series

Cyclic GMP-AMP synthase Inhibitor

Basic Description

Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Cyclic GMP-AMP synthase

Associated Targets

CGAS Tchem Cyclic GMP-AMP synthase 0 Activities

Discover Target: CGAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1R,2S)-2-[(7-oxo-5-phenyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]cyclohexane-1-carboxylic acid
INCHI	InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,21H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1
InChi Key	WGQGCLHXUPGUSZ-HIFRSBDPSA-N
Canonical SMILES	C1CCC(C(C1)C(=O)O)NC(=O)C2=CNN3C2=NC(=CC3=O)C4=CC=CC=C4
Isomeric SMILES	C1CC[C@@H]([C@@H](C1)C(=O)O)NC(=O)C2=CNN3C2=NC(=CC3=O)C4=CC=CC=C4
PubChem CID	137300622
MeSH Entry Terms	PF-06928215
Molecular Weight	380.4

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
F2204832	Certificate of Analysis	May 19, 2022	P420009
F2204839	Certificate of Analysis	May 19, 2022	P420009
F2204840	Certificate of Analysis	May 19, 2022	P420009
F2204841	Certificate of Analysis	May 19, 2022	P420009
F2204844	Certificate of Analysis	May 19, 2022	P420009
F2204852	Certificate of Analysis	May 19, 2022	P420009

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M et al.. (2017) Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.. PLoS One, 12 (9): (e0184843). [PMID:28934246]

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