PF-3758309 - 98%, high purity , CAS No.898044-15-0, Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of p21 (RAC1) activated kinase 2;Inhibitor of p21 (RAC1) activated kinase 3;Inhibitor of p21 (RAC1) activated kinase 4;Inhibitor of p21 (RAC1) activated kinase 5;Inhibitor of p21 (RAC1) activated kinase

Item Number

P127086

Grouped product items
SKU	Size	Availability	Price
P127086-5mg	5mg	In stock	$64.90
P127086-10mg	10mg	In stock	$94.90
P127086-25mg	25mg	In stock	$213.90
P127086-50mg	50mg	In stock	$284.90
P127086-100mg	100mg	In stock	$474.90

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Basic Description

Synonyms	PF-3758309\|898044-15-0\|PF-03758309\|(S)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-((2-methylthieno[3,2-d]pyrimidin-4-yl)amino)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide\|PF3758309\|PK459EA5I2\|N-((1S)-2-(Dimethylamino)-1-phenylethyl)-6,6-di
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	PF-3758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serin
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of p21 (RAC1) activated kinase 1;Inhibitor of p21 (RAC1) activated kinase 2;Inhibitor of p21 (RAC1) activated kinase 3;Inhibitor of p21 (RAC1) activated kinase 4;Inhibitor of p21 (RAC1) activated kinase 5;Inhibitor of p21 (RAC1) activated kinase

Names and Identifiers

Pubchem Sid	488200784
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200784
IUPAC Name	N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
INCHI	InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1
InChi Key	AYCPARAPKDAOEN-LJQANCHMSA-N
Canonical SMILES	CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)NC(CN(C)C)C5=CC=CC=C5)SC=C2
Isomeric SMILES	CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2
Alternate CAS	898044-15-0
PubChem CID	25227462
MeSH Entry Terms	PF 3758309;PF-3758309;PF3758309
Molecular Weight	490.62

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
D2320666	Certificate of Analysis	Mar 27, 2023	P127086
D2320670	Certificate of Analysis	Mar 27, 2023	P127086
D2320682	Certificate of Analysis	Mar 27, 2023	P127086
D2320683	Certificate of Analysis	Mar 27, 2023	P127086
D2320691	Certificate of Analysis	Mar 27, 2023	P127086
D2320843	Certificate of Analysis	Mar 27, 2023	P127086
D2320848	Certificate of Analysis	Mar 27, 2023	P127086
D2320853	Certificate of Analysis	Mar 27, 2023	P127086
D2320867	Certificate of Analysis	Mar 27, 2023	P127086
D2320886	Certificate of Analysis	Mar 27, 2023	P127086

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

References

1. Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M et al.. (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.. Proc Natl Acad Sci USA, 107 (20): (9446-51). [PMID:20439741]

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Basic Description