PF 5006739 - 98%, high purity , CAS No.1293395-67-1

Item Number

P288881

• Synonyms: 1293395-67-1|PF-5006739|4-{4-(4-Fluorophenyl)-1-[1-(1,2-Oxazol-3-Ylmethyl)piperidin-4-Yl]-1h-Imidazol-5-Yl}pyrimidin-2-Amine|CHEMBL4128865|PF 5006739|2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-|4-[4-
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: otent casein kinase 1δ/ε inhibitor (IC50values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effectsin vivo. Attenuates opioid drug seeking behavior in addictionin vivomodels.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads

Product Description

PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity.