| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P655421-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $220.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria In Vitro Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality. PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC 50 =1.113 µM) over hDHODH (IC 50 >50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC 50 values of both >20 µM, respectively in whole cell assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 1.113 µM (PfDHODH) IC50: >50 µM ( hDHODH) |
| Canonical SMILES | CCOC(=O)C1=C(CSC1=NC2=CC=C(C=C2)Cl)O |
|---|---|
| Molecular Weight | 297.76 |
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