PG 01 - ≥98%(HPLC), high purity , CAS No.853138-65-5, Activator of CFTR

Item Number

P286576

Grouped product items
SKU	Size	Availability	Price
P286576-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$152.90
P286576-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$454.90
P286576-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$771.90
P286576-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,737.90
P286576-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,126.90

CFTR potentiator; corrects F508del-CFTR conductance defect

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Basic Description

Synonyms	Phenylglycine-01\|853138-65-5\|PG 01\|PG-01\|PG01\|2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide\|CHEMBL1949980\|2-((2-1h-indol-3-ylacetyl)methylamino)-n-(4-isopropylphenyl)-2-phenylacetamide\|2-[(2-1H-indol-3-ylacetyl)methylami
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of CFTR
Product Description	Product description： PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM). PG01 increases ΔF508-CFTR Cl- current after adding Forskolin。

Names and Identifiers

IUPAC Name	2-[[2-(1H-indol-3-yl)acetyl]-methylamino]-2-phenyl-N-(4-propan-2-ylphenyl)acetamide
INCHI	InChI=1S/C28H29N3O2/c1-19(2)20-13-15-23(16-14-20)30-28(33)27(21-9-5-4-6-10-21)31(3)26(32)17-22-18-29-25-12-8-7-11-24(22)25/h4-16,18-19,27,29H,17H2,1-3H3,(H,30,33)
InChi Key	PQAYCXMQTUEDRD-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=CC=C(C=C1)NC(=O)C(C2=CC=CC=C2)N(C)C(=O)CC3=CNC4=CC=CC=C43
Isomeric SMILES	CC(C)C1=CC=C(C=C1)NC(=O)C(C2=CC=CC=C2)N(C)C(=O)CC3=CNC4=CC=CC=C43
WGK Germany	3
PubChem CID	4695397
Molecular Weight	439.55

PubChem CID

ChEMBL Ligand

CAS Registry No.

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
D2306809	Certificate of Analysis	Feb 08, 2023	P286576
D2306829	Certificate of Analysis	Feb 08, 2023	P286576
D2306836	Certificate of Analysis	Feb 08, 2023	P286576
D2306837	Certificate of Analysis	Feb 08, 2023	P286576
D2306872	Certificate of Analysis	Feb 08, 2023	P286576

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RIDADR	NONHforallmodesoftransport

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Basic Description