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PGF1α (Prostaglandin F1α) - 98%, high purity , CAS No.745-62-0, Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4

Moligand™
≥98%

CAS#: 745-62-0
Formula: C₂₀H₃₆O₅
Molecular Weight: 356.5
Beilstein Registry Number: 2704846
PubChem CID: 5280939

Item Number

P336179

Grouped product items
SKU	Size	Availability	Price	Qty
P336179-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$60.90
P336179-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$273.90

a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2)

View related series

CatSper1 Activator CatSper2 Activator CatSper3 Activator CatSper4 Activator

Basic Description

Synonyms	Prostaglandin f1alpha\|Prostaglandin F1\|745-62-0\|PGF1alpha\|PGF 1-alpha\|Prostaglandin f1-alpha\|Prostaglandin F1.alpha.\|MLS000069612\|9S,11R,15S-trihydroxy-13E-prostaenoic acid\|CHEBI:28852\|prostaglandin F1a\|WJ72O6860W\|7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of CatSper1;Activator of CatSper2;Activator of CatSper3;Activator of CatSper4
Product Description	Prostaglandin F1α (PGF1α) is a biosynthesis product from dihomo-γ-linolenic acid (DGLA) via the cyclooxygenaze (COX) pathway, and is a stable metabolite of prostacyclin (PGI2; sc-201231). By measuring the olfactory sensitivity of male salmon to F-type prostaglandins, studies show there is a possibility that they have a pheromonal role in Atlantic salmon. This compound also acts as smooth muscle relaxant, however, PGF1α is only half as active as PGF2α in inducing human respiratory smooth muscle contractions\|in vitro\|.

Associated Targets

CATSPER4 Tchem Cation channel sperm-associated protein 4 1 Activities

Discover Target: CATSPER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER1 Tchem Cation channel sperm-associated protein 1 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CATSPER3 Tchem Cation channel sperm-associated protein 3 1 Activities

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CATSPER2 Tchem Cation channel sperm-associated protein 2 1 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]heptanoic acid
INCHI	InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
InChi Key	DZUXGQBLFALXCR-CDIPTNKSSA-N
Canonical SMILES	CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O
Isomeric SMILES	CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1CCCCCCC(=O)O)O)O)O
WGK Germany	3
RTECS	GY4569700
PubChem CID	5280939
Molecular Weight	356.5
Beilstein	2704846

CAS Registry No.

ChEBI

PubChem CID

ChEMBL Ligand

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
D23181135	Certificate of Analysis	Mar 10, 2023	P336179
D23181139	Certificate of Analysis	Mar 10, 2023	P336179
D2325723	Certificate of Analysis	Mar 10, 2023	P336179

Solubility

Soluble in ethanol (50 mg/ml), water (>2 mg/ml) at 25° C, PBS (pH 7.2) (2.1 mg/ml), DMSO (50 mg/ml), and DMF (50 mg/ml).

Refractive Index

n20D1.56

Boil Point(°C)

~526.6° C at 760 mmHg (Predicted)

Melt Point(°C)

95-97° C

WGK Germany

RTECS

GY4569700

RIDADR

NONHforallmodesoftransport

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