Click Here for 5% Off Your First Aladdin Purchase!

Phenidone - 98.5%, high purity , CAS No.92-43-3

  • ≥98.5%
Item Number
P113217
Grouped product items
SKUSizeAvailabilityPrice Qty
P113217-5g
5g
In stock
$9.90
P113217-25g
25g
In stock
$19.90
P113217-100g
100g
In stock
$68.90
P113217-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$145.90

Basic Description

SynonymsPhenidone|92-43-3|1-PHENYL-3-PYRAZOLIDINONE|1-phenylpyrazolidin-3-one|1-Phenyl-3-pyrazolidone|Fenidon|3-Pyrazolidinone, 1-phenyl-|Pyrazolidinone, 1-phenyl-|1-Phenyl-3-oxopyrazolidine|2-Pyrazolin-3-ol, 1-phenyl-|1-P-3-P|1-Phenyl-pyrazolidin-3-one|1-Phenylp
Specifications & Purity≥98.5%
Shipped InNormal

Associated Targets

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RACGAP1 Tbio Rac GTPase-activating protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKCD Tclin Protein kinase C delta type 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLA2G1B Tchem Phospholipase A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLA2G2A Tchem Phospholipase A2, membrane associated 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488180278
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180278
IUPAC Name 1-phenylpyrazolidin-3-one
INCHI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
InChi Key CMCWWLVWPDLCRM-UHFFFAOYSA-N
Canonical SMILES C1CN(NC1=O)C2=CC=CC=C2
Isomeric SMILES C1CN(NC1=O)C2=CC=CC=C2
WGK Germany 2
RTECS UQ8750000
PubChem CID 7090
UN Number 2811
Packing Group III
Molecular Weight 162.19
Beilstein 131856
Reaxy-Rn 131856

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot NumberCertificate TypeDateItem
A23061002Certificate of AnalysisDec 03, 2022 P113217
A23061003Certificate of AnalysisDec 03, 2022 P113217
A2306853Certificate of AnalysisDec 03, 2022 P113217
A2306876Certificate of AnalysisDec 03, 2022 P113217
A2306896Certificate of AnalysisDec 03, 2022 P113217
A2306898Certificate of AnalysisDec 03, 2022 P113217
A2306983Certificate of AnalysisDec 03, 2022 P113217
J1816052Certificate of AnalysisAug 05, 2022 P113217
B2212023Certificate of AnalysisFeb 16, 2022 P113217

Chemical and Physical Properties

SensitivityLight Sensitive,Air Sensitive
Melt Point(°C)119-123°C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H411:Toxic to aquatic life with long lasting effects

H302:Harmful if swallowed

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 2
RTECS UQ8750000
Reaxy-Rn 131856
Class 6.1
Merck Index 7309

Related Documents

References

1. A Wakatsuki,C Izumiya,Y Okatani,Y Sagara.  (1999-07-08)  Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation..  Biology of the neonate,  76  ((2)): (84-91).  [PMID:10393992]
2. H C Kim,W K Jhoo,G Bing,E J Shin,M B Wie,W K Kim,K H Ko.  (2000-08-11)  Phenidone prevents kainate-induced neurotoxicity via antioxidant mechanisms..  Brain research,  874  ((1)): (15-23).  [PMID:10936219]
3. F Stanke-Labesque,P Devillier,P Bedouch,J L Cracowski,O Chavanon,G Bessard.  (2000-08-18)  Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition..  Cardiovascular research,  47  ((2)): (376-383).  [PMID:10946074]
4. P Rebuffat,F Aragona,C Tortorella,L K Malendowicz,G G Nussdorfer.  (2001-02-17)  Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex..  International journal of molecular medicine,  ((3)): (301-305).  [PMID:11179511]
5. C Audouin,N Mestdagh,M A Lassoie,R Houssin,J P Hénichart.  (2001-03-30)  N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase..  Bioorganic & medicinal chemistry letters,  11  ((6)): (845-848).  [PMID:11277534]
6. J C Bedick,H Tunaz,A R Nor Aliza,S M Putnam,M D Ellis,D W Stanley.  (2001-09-07)  Eicosanoids act in nodulation reactions to bacterial infections in newly emerged adult honey bees, Apis mellifera, but not in older foragers..  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP,  130  ((1)): (107-117).  [PMID:11544147]
7. John Meshki,Florin Tuluc,Ovidiu Bredetean,Zhongren Ding,Satya P Kunapuli.  (2003-11-14)  Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor..  American journal of physiology. Cell physiology,  286  ((2)): (C264-C271).  [PMID:14613890]
8. Monika Frey,Dieter Spiteller,Wilhelm Boland,Alfons Gierl.  (2004-04-28)  Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects..  Phytochemistry,  65  ((8)): (1047-1055).  [PMID:15110684]
9. Martin Heil,Sabine Greiner,Harald Meimberg,Ralf Krüger,Jean-Louis Noyer,Günther Heubl,K Eduard Linsenmair,Wilhelm Boland.  (2004-07-09)  Evolutionary change from induced to constitutive expression of an indirect plant resistance..  Nature,  430  ((6996)): (205-208).  [PMID:15241414]
10. Claudia Cusan,Giampiero Spalluto,Maurizio Prato,Michael Adams,Antje Bodensieck,Rudolf Bauer,Aurelia Tubaro,Paolo Bernardi,Tatiana Da Ros.  (2005-01-18)  Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors..  Farmaco (Societa chimica italiana : 1989),  60  ((1)): (7-13).  [PMID:15652362]
11. Changjong Moon,Meejung Ahn,Myung-Bok Wie,Hyung-Min Kim,Chang-Sung Koh,Seong-Chul Hong,Moon-Doo Kim,Naoyuki Tanuma,Yoh Matsumoto,Taekyun Shin.  (2005-02-22)  Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes..  Brain research,  1035  ((2)): (206-210).  [PMID:15722060]
12. Zhengyi Li,Dong-Young Choi,Eun-Joo Shin,Randy L Hunter,Chun Hui Jin,Myung-Bok Wie,Min Soo Kim,Seok Joo Park,Guoying Bing,Hyoung-Chun Kim.  (2008-09-02)  Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity..  Neuroscience letters,  445  ((1)): (1-6).  [PMID:18760329]
13. Torsten Hans Schroeder,Wolfgang Artur Krueger,Hans-Jürgen Dieterich,Boris Nohé.  (2008-03-01)  Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the inhibition of adhesion molecule expression on human umbilical vascular endothelial cells..  Biologics : targets & therapy,  ((1)): (151-160).  [PMID:19707438]
14. Maaike Bruinsma,Sarah van Broekhoven,Erik H Poelman,Maarten A Posthumus,Martin J Müller,Joop J A van Loon,Marcel Dicke.  (2009-10-07)  Inhibition of lipoxygenase affects induction of both direct and indirect plant defences against herbivorous insects..  Oecologia,  162  ((2)): (393-404).  [PMID:19806367]
15. Venkatesan Radhika,Christian Kost,Wilhelm Boland,Martin Heil.  (2010-02-23)  The role of jasmonates in floral nectar secretion..  PloS one,  ((2)): (e9265-e9265).  [PMID:20174464]
16. Ender Büyükgüzel,Hasan Tunaz,David Stanley,Kemal Büyükgüzel.  (2011-02-10)  The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor..  Journal of insect physiology,  57  ((4)): (501-507).  [PMID:21303676]
17. Jun-Hyung Kim,Myeong Seon Jeong,Dong-Yung Kim,Song Her,Myung-Bok Wie.  (2015-09-15)  Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells..  Neurochemistry international,  90  (204-214).  [PMID:26364578]
18. Wan Mohd Nuzul Hakimi Salleh,Mohd Fariz Kammil,Farediah Ahmad,Hasnah Mohd Sirat.  (2016-01-12)  Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum..  Natural product communications,  10  ((11)): (2005-2008).  [PMID:26749849]
19. Dong Duan,Sabine Fischer,Patrick Merz,Jochen Bogs,Michael Riemann,Peter Nick.  (2016-02-05)  An ancestral allele of grapevine transcription factor MYB14 promotes plant defence..  Journal of experimental botany,  67  ((6)): (1795-1804).  [PMID:26842984]
20. Ender Büyükgüzel,Meltem Erdem,Hasan Tunaz,Ceyhun Küçük,Utku Can Atılgan,David Stanley,Kemal Büyükgüzel.  (2016-11-27)  Inhibition of eicosanoid signaling leads to increased lipid peroxidation in a host/parasitoid system..  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,  204  (121-128).  [PMID:27887946]
21. Yangyang Luo,Ru Bai,Jing Li,Weidong Yang,Ruixiang Li,Qingyang Wang,Guifang Zhao,Dong Duan.  (2019-03-14)  The transcription factor MYB15 is essential for basal immunity (PTI) in Chinese wild grape..  Planta,  249  ((6)): (1889-1902).  [PMID:30864013]
22. Mandy Otto,Clarissa Bucher,Wantao Liu,Melanie Müller,Tobias Schmidt,Marina Kardell,Marvin Noel Driessen,Jan Rossaint,Eric R Gross,Nana-Maria Wagner.  (2020-06-26)  12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1..  The Journal of clinical investigation,  130  ((9)): (4999-5010).  [PMID:32584793]
23. M B Wie,Y J Cho,W K Jhoo,H C Kim.  (1999-10-03)  Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures..  Neuroscience letters,  272  ((2)): (91-94).  [PMID:10507549]
24. H Fujita,F Saito,T Sawada,T Kushiro,H Yagi,K Kanmatsuse.  (1999-10-19)  Lipoxygenase inhibition decreases neointimal formation following vascular injury..  Atherosclerosis,  147  ((1)): (69-75).  [PMID:10525127]
25. R Kumarathasan,F H Leenen.  (2000-06-30)  Is ATP a substrate for 15-lipoxygenase?.  Biochemistry and cell biology = Biochimie et biologie cellulaire,  78  ((2)): (87-91).  [PMID:10874469]
26. T Sen,A K Dhara,S Bhattacharjee,S Pal,A K Nag Chaudhuri.  (2002-07-12)  Antioxidant activity of the methanol fraction of Pluchea indica root extract..  Phytotherapy research : PTR,  16  ((4)): (331-335).  [PMID:12112288]
27. Eun-Seon Kim,Eunyoung Choi,Youngsun Kim,Kyoungwon Cho,Ayoung Lee,Jaehan Shim,Randeep Rakwal,Ganesh Kumar Agrawal,Oksoo Han.  (2003-12-20)  Dual positional specificity and expression of non-traditional lipoxygenase induced by wounding and methyl jasmonate in maize seedlings..  Plant molecular biology,  52  ((6)): (1203-1213).  [PMID:14682619]
28. Hasan Tunaz.  (2006-10-19)  Eicosanoid biosynthesis inhibitors influence mortality of Pieris brassicae larvae co-injected with fungal conidia..  Archives of insect biochemistry and physiology,  63  ((3)): (93-100).  [PMID:17048247]
29. Sumner H Burstein,Jeffrey K Adams,Heather B Bradshaw,Cristian Fraioli,Ronald G Rossetti,Rebecca A Salmonsen,John W Shaw,J Michael Walker,Robert E Zipkin,Robert B Zurier.  (2007-03-27)  Potential anti-inflammatory actions of the elmiric (lipoamino) acids..  Bioorganic & medicinal chemistry,  15  ((10)): (3345-3355).  [PMID:17383881]
30. Ivana Holková,Lýdia Bezáková,František Bilka,Andrea Balažová,Marián Vanko,Vítazoslava Blanáriková.  (2010-09-11)  Involvement of lipoxygenase in elicitor-stimulated sanguinarine accumulation in Papaver somniferum suspension cultures..  Plant physiology and biochemistry : PPB,  48  ((10-11)): (887-892).  [PMID:20829053]
31. J Peng,J J A van Loon,S Zheng,M Dicke.  (2011-02-12)  Herbivore-induced volatiles of cabbage (Brassica oleracea) prime defence responses in neighbouring intact plants..  Plant biology (Stuttgart, Germany),  13  ((2)): (276-284).  [PMID:21309974]
32. Joonyup Kim,Sara E Patterson,Brad M Binder.  (2012-12-12)  Reducing jasmonic acid levels causes ein2 mutants to become ethylene responsive..  FEBS letters,  587  ((2)): (226-230).  [PMID:23219920]
33. Woo-Ju Song,Myung-Seon Jeong,Dong-Min Choi,Kil-Nam Kim,Myung-Bok Wie.  (2019-07-25)  Zinc Oxide Nanoparticles Induce Autophagy and Apoptosis via Oxidative Injury and Pro-Inflammatory Cytokines in Primary Astrocyte Cultures..  Nanomaterials (Basel, Switzerland),  ((7)):   [PMID:31330912]

Solution Calculators