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Phenylbutazone - ≥98%(HPLC), high purity , CAS No.50-33-9, Inhibitor of COX-1;Inhibitor of COX-2

Moligand™
≥98%(HPLC)

CAS#: 50-33-9
Formula: C₁₉H₂₀N₂O₂
Molecular Weight: 308.37
Beilstein Registry Number: 24(5)5,400
MDL number: MFCD00005500
PubChem CID: 4781
PubChem SID: 488179856

Item Number

P129990

Grouped product items
SKU	Size	Availability	Price
P129990-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
P129990-25g	25g	In stock	$26.90
P129990-100g	100g	In stock	$95.90
P129990-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$209.90

Lipophilic NSAID. COX inhibitor.

View related series

COX-1 Inhibitor COX-2 Inhibitor

Basic Description

Synonyms	phenylbutazone\|50-33-9\|4-Butyl-1,2-diphenylpyrazolidine-3,5-dione\|Butapirazol\|Butazolidin\|Butadion\|Diphenylbutazone\|Butazolidine\|Fenibutazona\|Fenilbutazona\|Fenylbutazon\|Intrabutazone\|Artrizin\|Butacote\|Butadiona\|Diphebuzol\|Ecobutazone\|Fenibutol\|Intrazone\|P
Specifications & Purity	≥98%(HPLC)
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of COX-1;Inhibitor of COX-2
Product Description	Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis. An inhibitor of Cox.

Associated Targets

NAPRT Tchem Nicotinate phosphoribosyltransferase 2 Activities

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 1 Activities

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 1 Activities

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179856
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179856
IUPAC Name	4-butyl-1,2-diphenylpyrazolidine-3,5-dione
INCHI	InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
InChi Key	VYMDGNCVAMGZFE-UHFFFAOYSA-N
Canonical SMILES	CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES	CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
WGK Germany	3
RTECS	UQ8225000
PubChem CID	4781
UN Number	2811
Packing Group	I
Molecular Weight	308.37
Beilstein	24(5)5,400
Reaxy-Rn	290080

DrugBank Ligand

PubChem CID

CAS Registry No.

ChEMBL Ligand

Wikipedia

RCSB PDB Ligand

DrugCentral Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
H2406058	Certificate of Analysis	Aug 14, 2024	P129990
G2403650	Certificate of Analysis	Apr 13, 2024	P129990
G2403651	Certificate of Analysis	Apr 13, 2024	P129990
G2403652	Certificate of Analysis	Apr 13, 2024	P129990
L2304026	Certificate of Analysis	Dec 13, 2023	P129990
K2126298	Certificate of Analysis	Sep 20, 2023	P129990
B2315102	Certificate of Analysis	Feb 24, 2023	P129990
I2221047	Certificate of Analysis	Sep 26, 2022	P129990

Solubility

Soluble in water (1 mg/ml at 25 °C), ethanol (62 mg/ml at 25 °C), methanol, DMSO (62 mg/ml at 25 °C), and DMF (25 mg/ml).

Melt Point(°C)

106 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H351:Suspected of causing cancer H317:May cause an allergic skin reaction H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3
RTECS	UQ8225000
Reaxy-Rn	290080
Class	6.1
Merck Index	7277

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