PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis
In Vitro:PI3K/AKT-IN-1 (compound 7f) (0.04-100 µM; 48 hours) has high cytotoxic activity on both cell lines with better activity on leukaemia cell line (K562 IC 50 =2.62 µM) than on the breast cancer cell line (MCF-7 IC 50 =3.22 µM). PI3K/AKT-IN-1 (2.62 µM) c
In Vivo:PI3K/AKT-IN-1 (2000mg/kg; p.o.; single) is non-toxic and is well tolerated by experimental animals. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female rats (180-200g)Dosage: 2000
Biological Activity:PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis
