| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P661661-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $256.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis IC50& Target:PI3Kγ 6.99 μM (IC 50 ) PI3Kδ 4.01 μM (IC 50 ) In Vitro:PI3K/AKT-IN-1 (compound 7f) (0.04-100 µM; 48 hours) has high cytotoxic activity on both cell lines with better activity on leukaemia cell line (K562 IC 50 =2.62 µM) than on the breast cancer cell line (MCF-7 IC 50 =3.22 µM). PI3K/AKT-IN-1 (2.62 µM) c In Vivo:PI3K/AKT-IN-1 (2000mg/kg; p.o.; single) is non-toxic and is well tolerated by experimental animals. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female rats (180-200g)Dosage: 2000 Biological Activity:PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis |
| Canonical SMILES | N#CC1=C(N/N=C/C2=CC(OC)=C(OC)C(OC)=C2)N=C(SC)N=C1C3=CC=C(OC)C=C3 |
|---|---|
| Molecular Weight | 465.52 |
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