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pifusertib , Serine/threonine-protein kinase AKT negative allosteric modulator, CAS No.1402602-94-1, Serine/threonine-protein kinase AKT negative allosteric modulator
Basic Description
Synonyms | TAS-117|UNII-QI52W1ZIIB|pifusertib|1402602-94-1|TAS 117|QI52W1ZIIB|trans-3-Amino-1-methyl-3-(4-(3-phenyl-5H-imidazo(1,2-C)pyrido(3,4-E)(1,3)oxazin-2-yl)phenyl)cyclobutanol|3-amino-1-methyl-3-[4-(5-phenyl-8-oxa-3,6,12-triazatricyclo[7.4.0.02,6]trideca-1(9) |
Grade | Moligand™ |
Action Type | INHIBITOR, NEGATIVE ALLOSTERIC MODULATOR |
Mechanism of action | Serine/threonine-protein kinase AKT negative allosteric modulator |
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Names and Identifiers
IUPAC Name | 3-amino-1-methyl-3-[4-(5-phenyl-8-oxa-3,6,12-triazatricyclo[7.4.0.02,6]trideca-1(9),2,4,10,12-pentaen-4-yl)phenyl]cyclobutan-1-ol |
INCHI | InChI=1S/C26H24N4O2/c1-25(31)14-26(27,15-25)19-9-7-17(8-10-19)22-23(18-5-3-2-4-6-18)30-16-32-21-11-12-28-13-20(21)24(30)29-22/h2-13,31H,14-16,27H2,1H3/t25-,26- |
InChi Key | AIFGVDXMHWGOGJ-DIVCQZSQSA-N |
Canonical SMILES | C[C@@]1(O)C[C@@](N)(C1)c1ccc(cc1)c1c(n2COc3c(cncc3)c2n1)c1ccccc1 |
Isomeric SMILES | CC1(CC(C1)(C2=CC=C(C=C2)C3=C(N4COC5=C(C4=N3)C=NC=C5)C6=CC=CC=C6)N)O |
PubChem CID | 66555816 |
Molecular Weight | 424.5 |
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References
1. Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J et al.. (2014) Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.. Cancer Res, 74 (16): (4458-69). [PMID:24934808] |
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