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PIK-III , CAS No.P612835, Inhibitor of phosphatidylinositol 3-kinase catalytic subunit type 3
Basic Description Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of phosphatidylinositol 3-kinase catalytic subunit type 3
Names and Identifiers IUPAC Name 4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amine INCHI InChI=1S/C17H17N7/c18-16-21-10-13(15(23-16)9-11-1-2-11)14-5-8-20-17(24-14)22-12-3-6-19-7-4-12/h3-8,10-11H,1-2,9H2,(H2,18,21,23)(H,19,20,22,24) InChi Key XXSDLQLNIVFIJI-UHFFFAOYSA-N Canonical SMILES Nc1ncc(c(n1)CC1CC1)c1ccnc(n1)Nc1ccncc1 Isomeric SMILES C1CC1CC2=NC(=NC=C2C3=NC(=NC=C3)NC4=CC=NC=C4)N PubChem CID 67983123
References 1. Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G et al. . (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.. Nat Cell Biol, 16 (11): (1069-79). [PMID:25327288 ] 2. Williams CG, Jureka AS, Silvas JA, Nicolini AM, Chvatal SA, Carlson-Stevermer J, Oki J, Holden K, Basler CF. (2021) Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.. Cell Rep, 129 (3): (109479). [PMID:34320401 ]
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