| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P655520-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $418.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity In Vitro PIM1-IN-1 (Compound 42) exhibits antiproliferative activity, with GI 50 of 1.48 µM for melanoma cell line SKMEL-19. PIM1-IN-1 has significant synergistic effect combined with different antitumoral agents in different tumor cell lines. PIM1-IN-1 (2.5, 5, or 10 µM, 24 hours) induces apoptosis in SKMEL19 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: SKMEL19 cells Concentration: 2.5, 5, or 10 µM Incubation Time: 24 hours Result: Regulated cell cycle, induced cell apopsis in SKMEL19 cells. In Vivo PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:PIM1 7 nM (IC 50 ) PIM3 70 nM (IC 50 ) PIM2 5530 nM (IC 50 ) |
| Canonical SMILES | COCCN1C2=C(C3=NN=C(C4=NC5=C(NCC6CCNCC6)C=CC=C5C=C4)N3N=C2)OCC1 |
|---|---|
| Molecular Weight | 474.56 |
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