Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P107401-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $206.90 |
TRPV1 agonist
Synonyms | BSPBio_002515 | MLS002153830 | Piperine, >=97% | starbld0008505 | NSC757803 | NSC-757803 | Piperidine, (E,E)- | Bioperine;1-Piperoylpiperidine | EINECS 202-348-0 | HY-N0144 | PIPERINE [WHO-DD] | (1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidi |
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Specifications & Purity | Moligand™, analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | TRPV1 agonist (EC 50 = 38 μM). Non-selective GABA A agonist (EC 50 = 60 μM). Shows neuroprotective, anti-inflammatory, and antioxidant effects in vivo. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | analytical standard, Moligand™ |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. |
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IUPAC Name | (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one |
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INCHI | InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+ |
InChi Key | MXXWOMGUGJBKIW-YPCIICBESA-N |
Canonical SMILES | C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3 |
Isomeric SMILES | C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3 |
WGK Germany | 3 |
RTECS | TN2321500 |
PubChem CID | 638024 |
Molecular Weight | 285.34 |
Beilstein | 90741 |
Reaxy-Rn | 90741 |
Enter Lot Number to search for COA:
Solubility | Soluble in ethanol (57 mg/ml), DMSO (57 mg/ml), alcohol (66.67 mg/ml), chloroform (588.24 mg/ml), and ether (27.78 mg/ml). |
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Sensitivity | Light,Air & Moisture Sensitive. |
Melt Point(°C) | 128-132°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
WGK Germany | 3 |
RTECS | TN2321500 |
Reaxy-Rn | 90741 |
Merck Index | 7472 |
1. Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li. (2023) Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin. Food & Function, 14 (14): (6422-6431). [PMID:37395089] |
2. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai, Baoxin Zhang. (2023) Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis. BIOORGANIC CHEMISTRY, (106589). [PMID:37320912] |
3. Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. (2023) The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. FOOD CHEMISTRY, 420 (136119). [PMID:37060667] |
4. Mengmeng Wang, Bin Yang, Zongyi Ren, Jietao Liu, Chenwang Lu, Haifeng Jiang, Fei Ling, Gaoxue Wang, Tianqiang Liu. (2022) Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture. JOURNAL OF FISH DISEASES, 46 (3): (261-271). [PMID:36504104] |
5. Ning Jia, Pengfei Guo, Kaiyuan Zhang, Chen Liu, Ruihao Chen, Zhe Liu, Qian Ye, Hongqiang Wang. (2022) Defect Passivation by Natural Piperine Molecule Enabling for Stable Perovskite Solar Cells with Efficiencies over 23%. ACS Sustainable Chemistry & Engineering, 10 (49): (16359–16367). [PMID:] |
6. Zhang Chaohua, Gu Fenglin, Hu Weicheng, Wu Guiping, Chen Weijun, Dong Conghui, Niu Zhiqiang. (2022) Effect of extraction technique on chemical compositions and antioxidant activities of freeze-dried green pepper. Frontiers in Nutrition, 9 [PMID:36118756] |
7. Ligang Yu, Yong Li, Yukun Yang, Caixia Guo, Meiping Li. (2022) Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4646-4655). [PMID:] |
1. Li R et al.. (2021) Piperine promotes autophagy flux by P2RX4 activation in SNCA/a-synuclein-induced Parkinson disease model.. Autophagy, (1-17). [PMID:34092198] |
2. 陈帅. (2020) Core-shell nanoparticles for co-encapsulation of coenzyme Q10 and piperine: Surface engineering of hydrogel shell around protein core. Food Hydrocolloids, 1 (103): (105651). [PMID:] |
3. Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li. (2023) Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin. Food & Function, 14 (14): (6422-6431). [PMID:37395089] |
4. Miao Zhong, Lingzhen Chen, Yue Tao, Jintao Zhao, Bingbing Chang, Fang Zhang, Jingwen Tu, Wenqing Cai, Baoxin Zhang. (2023) Synthesis and evaluation of Piperine analogs as thioredoxin reductase inhibitors to cause oxidative stress-induced cancer cell apoptosis. BIOORGANIC CHEMISTRY, (106589). [PMID:37320912] |
5. Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. (2023) The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. FOOD CHEMISTRY, 420 (136119). [PMID:37060667] |
6. Mengmeng Wang, Bin Yang, Zongyi Ren, Jietao Liu, Chenwang Lu, Haifeng Jiang, Fei Ling, Gaoxue Wang, Tianqiang Liu. (2022) Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture. JOURNAL OF FISH DISEASES, 46 (3): (261-271). [PMID:36504104] |
7. Ning Jia, Pengfei Guo, Kaiyuan Zhang, Chen Liu, Ruihao Chen, Zhe Liu, Qian Ye, Hongqiang Wang. (2022) Defect Passivation by Natural Piperine Molecule Enabling for Stable Perovskite Solar Cells with Efficiencies over 23%. ACS Sustainable Chemistry & Engineering, 10 (49): (16359–16367). [PMID:] |
8. Zhang Chaohua, Gu Fenglin, Hu Weicheng, Wu Guiping, Chen Weijun, Dong Conghui, Niu Zhiqiang. (2022) Effect of extraction technique on chemical compositions and antioxidant activities of freeze-dried green pepper. Frontiers in Nutrition, 9 [PMID:36118756] |
9. Ligang Yu, Yong Li, Yukun Yang, Caixia Guo, Meiping Li. (2022) Inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products formation in a bovine serum albumin–fructose model. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (7): (4646-4655). [PMID:] |