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Piperine - 97%, high purity , CAS No.94-62-2, Activator of TRPV1

  • Moligand™
  • ≥97%
Item Number
P107402
Grouped product items
SKUSizeAvailabilityPrice Qty
P107402-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9.90
P107402-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$28.90
P107402-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$130.90
P107402-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$469.90
View related series
TRPV1 Activator

Basic Description

Synonymspiperine|94-62-2|1-Piperoylpiperidine|Piperin|Bioperine|7780-20-3|Piperoylpiperidine|FEMA No. 2909|(E,E)-1-piperoylpiperidine|Piperidine, 1-piperoyl-, (E,E)-|(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one|CCRIS 5572|N-[(E,E)-P
Specifications & PurityMoligand™, ≥97%
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of TRPV1
Product Description

Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
A black pepper extract TRPV1 activator.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DHODH Tclin Dihydroorotate dehydrogenase (quinone), mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABCB1 Tchem Multidrug resistance protein 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1H4 Tclin Bile acid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSD Tchem Cathepsin D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRCA1 Tchem Breast cancer type 1 susceptibility protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A1 Tchem Cytochrome P450 1A1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATXN2 Tbio Ataxin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALB Tchem Serum albumin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AHR Tclin Aryl hydrocarbon receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TPR Tbio Nucleoprotein TPR 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMPD1 Tchem Sphingomyelin phosphodiesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NPC1 Tchem NPC intracellular cholesterol transporter 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
INCHI InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
InChi Key MXXWOMGUGJBKIW-YPCIICBESA-N
Canonical SMILES C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
Isomeric SMILES C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3
WGK Germany 3
RTECS TN2321500
PubChem CID 638024
Molecular Weight 285.34
Beilstein 90741
Reaxy-Rn 90741

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
K2228597Certificate of AnalysisDec 08, 2022 P107402
K2228618Certificate of AnalysisDec 08, 2022 P107402
K2228620Certificate of AnalysisDec 08, 2022 P107402
K2228658Certificate of AnalysisDec 08, 2022 P107402
E1824062Certificate of AnalysisApr 11, 2022 P107402

Chemical and Physical Properties

SolubilitySoluble in ethanol (57 mg/ml), DMSO (57 mg/ml), alcohol (66.67 mg/ml), chloroform (588.24 mg/ml), and ether (27.78 mg/ml).
SensitivityLight,Air & Moisture Sensitive.
Melt Point(°C)128-132°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

WGK Germany 3
RTECS TN2321500
Reaxy-Rn 90741
Merck Index 7472

Related Documents

References

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17. S Chuchawankul,N Khorana,Y Poovorawan.  (2012-04-27)  Piperine inhibits cytokine production by human peripheral blood mononuclear cells..  Genetics and molecular research : GMR,  11  ((1)): (617-627).  [PMID:22535397]
18. Kumar Vaibhav,Pallavi Shrivastava,Hayate Javed,Andleeb Khan,Md Ejaz Ahmed,Rizwana Tabassum,Mohd Moshahid Khan,Gulrana Khuwaja,Farah Islam,M Saeed Siddiqui,Mohammed M Safhi,Fakhrul Islam.  (2012-06-07)  Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model..  Molecular and cellular biochemistry,  367  ((1-2)): (73-84).  [PMID:22669728]
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22. V Sama,M Nadipelli,P Yenumula,M R Bommineni,R Mullangi.  (2012-07-04)  Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide..  Arzneimittel-Forschung,  62  ((8)): (384-388).  [PMID:22753154]
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35. Yue-Ming Wang,Wenwei Lin,Sergio C Chai,Jing Wu,Su Sien Ong,Erin G Schuetz,Taosheng Chen.  (2013-05-28)  Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1..  Toxicology and applied pharmacology,  272  ((1)): (96-107).  [PMID:23707768]
36. Xue-Mei Bao,Sheng-Sang Na,Jing-Kun Lu.  (2013-05-31)  [Studies of effective part group of piperine to regulating lipid]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((6)): (909-913).  [PMID:23717978]
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38. Xiaozhou Ying,Kehe Yu,Xiaowei Chen,Hua Chen,Jianjun Hong,Shaowen Cheng,Lei Peng.  (2013-09-28)  Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells..  Cellular immunology,  285  ((1-2)): (49-54).  [PMID:24071564]
39. Yi Lin,Jianping Xu,Hehe Liao,Lu Li,Lei Pan.  (2013-11-26)  Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway..  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,  35  ((4)): (3305-3310).  [PMID:24272201]
40. Laia Rofes,Viridiana Arreola,Alberto Martin,Pere Clavé.  (2013-12-12)  Effect of oral piperine on the swallow response of patients with oropharyngeal dysphagia..  Journal of gastroenterology,  49  ((12)): (1517-1523).  [PMID:24326980]
41. Kristin N Adams,John D Szumowski,Lalita Ramakrishnan.  (2014-02-18)  Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs..  The Journal of infectious diseases,  210  ((3)): (456-466).  [PMID:24532601]
42. Ranjit K Harwansh,Kakali Mukherjee,Santanu Bhadra,Amit Kar,Shiv Bahadur,Achintya Mitra,Pulok K Mukherjee.  (2014-04-03)  Cytochrome P450 inhibitory potential and RP-HPLC standardization of trikatu--a Rasayana from Indian Ayurveda..  Journal of ethnopharmacology,  153  ((3)): (674-681).  [PMID:24690772]
43. B Pragnya,J S L Kameshwari,B Veeresh.  (2014-05-08)  Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice..  Behavioural brain research,  270  (86-94).  [PMID:24803211]
44. Bahman Khameneh,Milad Iranshahy,Morteza Ghandadi,Davod Ghoochi Atashbeyk,Bibi Sedigheh Fazly Bazzaz,Mehrdad Iranshahi.  (2014-05-21)  Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistant Staphylococcus aureus..  Drug development and industrial pharmacy,  41  ((6)): (989-994).  [PMID:24842547]
45. Sandeep Sharma,Nitin Pal Kalia,Pankaj Suden,Prashant Singh Chauhan,Manoj Kumar,Anshu Beulah Ram,Anamika Khajuria,Sarang Bani,Inshad Ali Khan.  (2014-06-02)  Protective efficacy of piperine against Mycobacterium tuberculosis..  Tuberculosis (Edinburgh, Scotland),  94  ((4)): (389-396).  [PMID:24880706]
46. Angela Schöffmann,Laurin Wimmer,Daria Goldmann,Sophia Khom,Juliane Hintersteiner,Igor Baburin,Thomas Schwarz,Michael Hintersteininger,Peter Pakfeifer,Mouhssin Oufir,Matthias Hamburger,Thomas Erker,Gerhard F Ecker,Marko D Mihovilovic,Steffen Hering.  (2014-06-07)  Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives..  Journal of medicinal chemistry,  57  ((13)): (5602-5619).  [PMID:24905252]
47. Shanmugam Ramaswamy,Gowthamarajan Kuppuswamy,Priyanka Dwarampudi,Madhuri Kadiyala,Lokesh Menta,Elango Kannan.  (2014-07-13)  Development and validation of simultaneous estimation method for curcumin and piperine by RP-UFLC..  Pakistan journal of pharmaceutical sciences,  27  ((4)): (901-906).  [PMID:25015458]
48. Chiyako Shimada,Yoshihiro Uesawa,Mariko Ishihara,Hajime Kagaya,Taisei Kanamoto,Shigemi Terakubo,Hideki Nakashima,Koichi Takao,Takaki Miyashiro,Yoshiaki Sugita,Hiroshi Sakagami.  (2014-09-10)  Quantitative structure-cytotoxicity relationship of piperic acid amides..  Anticancer research,  34  ((9)): (4877-4884).  [PMID:25202069]
49. Kang Pa Lee,Kwan Lee,Won-Hwan Park,Hyuck Kim,Heeok Hong.  (2014-11-11)  Piperine inhibits platelet-derived growth factor-BB-induced proliferation and migration in vascular smooth muscle cells..  Journal of medicinal food,  18  ((2)): (208-215).  [PMID:25384161]
50. Alex E Grill,Brenda Koniar,Jayanth Panyam.  (2014-11-26)  Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin..  Drug delivery and translational research,  ((4)): (344-352).  [PMID:25422796]
51. Anna L Greenshields,Carolyn D Doucette,Kimberly M Sutton,Laurence Madera,Henry Annan,Paul B Yaffe,Allison F Knickle,Zhongmin Dong,David W Hoskin.  (2014-12-03)  Piperine inhibits the growth and motility of triple-negative breast cancer cells..  Cancer letters,  357  ((1)): (129-140).  [PMID:25444919]
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