Pitstop ® 2 - negative control - ≥99%, high purity

  • ≥98%
Item Number
P276015
Grouped product items
SKUSizeAvailabilityPrice Qty
P276015-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90
P276015-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
P276015-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$429.90
P276015-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$959.90

Negative control of grid protein inhibitor Pitstop-2

View related series
Clathrin inhibitor

Basic Description

Synonyms5-(4-Bromobenzylidene)-2-(naphthalen-1-ylamino)-1,3-thiazol-4(5H)-one
Specifications & Purity≥98%
Biochemical and Physiological MechanismsNegative control for clathrin inhibitor Pitstop ® 2 which is of the same chemical class and has a highly related structure to Pitstop ® 2.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Pitnot-2 is an inactive analog of clathrin inhibitor Pitstop 2. Pitnot-2 can be used as negative control.

Names and Identifiers

Molecular Weight 409.30

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM

Related Documents

References

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3. Liashkovich I et al..  (2015)  Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier..  Sci Rep,  (9994).  [PMID:25944393]
4. Morinelli TA et al..  (2015)  Clathrin-dependent internalization of the angiotensin II AT1A receptor links receptor internalization to COX-2 protein expression in rat aortic vascular smooth muscle cells..  Eur J Pharmacol,  748  (143-8).  [PMID:25542758]
5. Abdul-Salam VB et al..  (2019)  CLIC4/Arf6 Pathway..  Circ Res,  124  (52-65).  [PMID:30582444]
6. Chang HF et al..  (2016)  Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes..  J Immunol,  197  (6): (2473-84).  [PMID:27527597]
7. Gourlaouen M et al..  (2013)  Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells..  J Biol Chem,  288  (11): (7467-80).  [PMID:23341459]
8. Albecka A et al..  (2016)  HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis..  Traffic,  17  (21-39).  [PMID:26459807]
9. Chia PZ et al..  (2013)  Intracellular Itinerary of Internalised ß-Secretase, BACE1, and Its Potential Impact on ß-Amyloid Peptide Biogenesis..  Traffic,      [PMID:23773724]
10. Meng J et al..  (2013)  Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons..  FASEB J,      [PMID:23640057]
11. Merriam LA et al..  (2013)  Pituitary adenylate cyclase 1 receptor internalization and endosomal signaling mediate the pituitary adenylate cyclase activating polypeptide-induced increase in guinea pig cardiac neuron excitability..  J Neurosci,  33  (10): (4614-22).  [PMID:23467377]
12. Baranov MV et al..  (2014)  Podosomes of dendritic cells facilitate antigen sampling..  J Cell Sci,  127  (Pt 5): (1052-64).  [PMID:24424029]
13. Martínez-Muñoz L et al..  (2018)  Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function..  Mol Cell,  70  (106-119.e10).  [PMID:29625032]
14. Králová J et al..  (2022)  Sterolight as imaging tool to study sterol uptake, trafficking and efflux in living cells..  Sci Rep,  12  (6264).  [PMID:35428843]

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