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Pizotifen - >98.0%(HPLC), high purity , CAS No.15574-96-6, Antagonist of 5-HT 1A receptor
Basic Description Synonyms Pizotifen|15574-96-6|PIZOTYLINE|Sandomigran|Litec|Sandomygran|BC-105|Pizotyline [USAN]|Pizotifenum|Pizotifene|Pizotifeno|BC 105|Pizotifan|4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine|Pizotifen [INN]|4-(9,10-Dihydro- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of 5-HT 1A receptor Product Description Pizotifen (BC-105) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site.
Names and Identifiers IUPAC Name 1-methyl-4-(6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene)piperidine INCHI InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3 InChi Key FIADGNVRKBPQEU-UHFFFAOYSA-N Canonical SMILES CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1 Isomeric SMILES CN1CCC(=C2C3=C(CCC4=CC=CC=C42)SC=C3)CC1 WGK Germany 3 RTECS TM7165000 Alternate CAS 15574-96-6 PubChem CID 27400 MeSH Entry Terms BC 105;BC-105;BC105;Pizotifen;Pizotyline;Polomigran;Sandomigran Molecular Weight 295.44 Reaxy-Rn 753534
Chemical and Physical Properties Solubility DMSO : 20 mg/mL (67.70 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) Melt Point(°C) 149 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
WGK Germany 3 RTECS TM7165000 Reaxy-Rn 753534 Merck Index 7515
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C2011116