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PKI166 - ≥98%, high purity , Epidermal growth factor receptor erbB1 inhibitor, CAS No.187724-61-4, Epidermal growth factor receptor erbB1 inhibitor

Moligand™
≥98%

CAS#: 187724-61-4
Formula: C₂₀H₁₈N₄O
Molecular Weight: 330.38
PubChem CID: 6918403

Item Number

P612856

Grouped product items
SKU	Size	Availability	Price
P612856-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$48.90
P612856-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$115.90
P612856-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$188.90
P612856-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$376.90

View related series

EGFR epidermal growth factor receptor Inhibitor JAK/STAT Signaling Protein Tyrosine Kinase/RTK VEGFR

Basic Description

Synonyms	PKI-166\|187724-61-4\|PKI166\|PKI 166\|9RIE5HW38P\|NVP-PKI166\|CGP-75166\|CGP75166\|CGP 75166\|UNII-9RIE5HW38P\|4-(4-((1-phenylethyl)amino)-7H-pyrrolo(2,3-d)pyrimidin-6-yl)-phenol, R-\|4-phenethylamino-6-(yderoxyl)phenyl-7H-pyrrolo(2,3-d)pyrimidine\|4-[4-[[(1R)-1-phe
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	PKI-166 is a potent, selective and orally available EGF-R tyrosine kinase inhibitor. PKI-166 potently inhibits the growth and metastasis of many human cancers including human pancreatic cancer.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Epidermal growth factor receptor erbB1 inhibitor
Product Description	PKI-166 is a potent, selective and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM.

Names and Identifiers

IUPAC Name	4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol
INCHI	InChI=1S/C20H18N4O/c1-13(14-5-3-2-4-6-14)23-19-17-11-18(24-20(17)22-12-21-19)15-7-9-16(25)10-8-15/h2-13,25H,1H3,(H2,21,22,23,24)/t13-/m1/s1
InChi Key	XRYJULCDUUATMC-CYBMUJFWSA-N
Canonical SMILES	OC(C=C1)=CC=C1C2=CC3=C(N2)N=CN=C3N[C@H](C)C4=CC=CC=C4
Isomeric SMILES	C[C@H](C1=CC=CC=C1)NC2=NC=NC3=C2C=C(N3)C4=CC=C(C=C4)O
WGK Germany	3
PubChem CID	6918403
Molecular Weight	330.38

ChEMBL Ligand

CHEMBL1963502

PubChem CID

6918403

CAS Registry No.

187724-61-4

Solubility

DMSO: 27.5 mg/mL (83.23 mM)

Sensitivity

light & air sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RIDADR	UN28116.1/PGIII

References

1. Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH. (2011) Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.. Eur J Med Chem, 46 (12): (6002-14). [PMID:22018877]
2. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033]

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PKI166 - ≥98%, high purity , Epidermal growth factor receptor erbB1 inhibitor, CAS No.187724-61-4, Epidermal growth factor receptor erbB1 inhibitor

Basic Description

Product Properties

Associated Targets

EGFR Tclin Epidermal growth factor receptor 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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