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PKR-IN-C51 - 99%, high purity , CAS No.1314594-23-4

  • ≥99%
Item Number
P650584
Grouped product items
SKUSizeAvailabilityPrice Qty
P650584-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$160.90
P650584-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$260.90
P650584-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$500.90
P650584-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$800.90
P650584-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsPKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC 50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages.
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC 50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages

Form:Solid

IC50& Target:IC50: 9 μM (double-stranded RNA-activated protein kinase (PKR))

Associated Targets

EIF2AK2 Tchem Interferon-induced, double-stranded RNA-activated protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[2-(1H-indol-3-yl)ethyl]-4-(2-methyl-1H-indol-3-yl)pyrimidin-2-amine
INCHI InChI=1S/C23H21N5/c1-15-22(18-7-3-5-9-20(18)27-15)21-11-13-25-23(28-21)24-12-10-16-14-26-19-8-4-2-6-17(16)19/h2-9,11,13-14,26-27H,10,12H2,1H3,(H,24,25,28)
InChi Key IDAWNFCAFDXMER-UHFFFAOYSA-N
Canonical SMILES CC1=C(C2=CC=CC=C2N1)C3=NC(=NC=C3)NCCC4=CNC5=CC=CC=C54
Isomeric SMILES CC1=C(C2=CC=CC=C2N1)C3=NC(=NC=C3)NCCC4=CNC5=CC=CC=C54
PubChem CID 53307873
Molecular Weight 367.45

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO : 125 mg/mL (340.18 mM; ultrasonic and warming and heat to 60°C)

Related Documents

Solution Calculators