Click Here for 5% Off Your First Aladdin Purchase!

PMS2 Antibody - Primary antibody, specific to PMS2, Rabbit IgG

Features and benefits
  • Specifications & Purity: ExactAb™, Validated, Carrier Free, 0.5 mg/mL
  • Short Overview:

    pAb; Rabbit anti Human PMS2 Antibody; WB, IHC; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
Item Number
Ab122454
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab122454-10μl (Trial Size)
Apply for free trial size(?)
Every year, as a valued customer, you have the exclusive opportunity to explore and enjoy three different trial products of your choice, absolutely free!
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
Ab122454-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab122454-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab122454-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,599.90

pAb; Rabbit anti Human PMS2 Antibody; WB, IHC; Unconjugated

View related series
Accession#:P54278 Gene ID:5395 PMS2

Basic Description

Product NamePMS2 Antibody - Primary antibody, specific to PMS2, Rabbit IgG
SynonymsDNA mismatch repair gene homologueantibody; DNA mismatch repair protein PMS2 antibody; H_DJ0042M02.9 antibody; HNPCC4 antibody; Mismatch repair endonuclease PMS2 antibody; Mismatch repair gene PMSL2 antibody; MLH4 antibody; PMS 2 antibody; PMS1 homolog 2
Specifications & PurityExactAb™, Validated, Carrier Free, 0.5 mg/mL
Host speciesRabbit
SpecificityPMS2
ImmunogenA synthetic peptide derived from human PMS2 (AA 9-24)
Positive ControlWB: Jurkat, HeLa and SK-N-SH cell lysates. IHC: Human tonsil tissue.
ConjugateUnconjugated
GradeCarrier Free, ExactAb™, Validated

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.5 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InDry ice
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

PMS2 Antibody (Ab122454) - Western Blot
All lanes: PMS2 Antibody (Ab122454) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 96 kDa
Observed band size: 48, 54, 107 kDa
Exposure time: 16.5 s

PMS2 Antibody (Ab122454) - IHC
Immunohistochemistry analysis of paraffin-embedded Human tonsil using PMS2 Antibody (Ab122454). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Application

ApplicationNotes
WB

1/500-1/1000

IHC

1/50 - 1/100

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0404020Certificate of AnalysisApr 01, 2024 Ab122454
ZJ24F0404019Certificate of AnalysisApr 01, 2024 Ab122454

Related Documents

Product Questions

Product Questions

Sign In Hover me Please sign in to submit a question
No questions yet. Be the first to ask the question!

Reviews

Customer Reviews

References

1. Hamilton, S R SR and 9 more authors..  (1995)  The molecular basis of Turcot's syndrome..  The New England journal of medicine,    (30):   [PMID:7661930]
2. Nicolaides, N C NC and 9 more authors..  (1994)  Mutations of two PMS homologues in hereditary nonpolyposis colon cancer..  Nature,    (1):   [PMID:8072530]
3. Miyaki, M M and 15 more authors..  (1997)  Drastic genetic instability of tumors and normal tissues in Turcot syndrome..  Oncogene,    (4):   [PMID:9419979]
4. Wang, Q Q and 10 more authors..  ()  Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer..  Human genetics,      [PMID:10480359]
5. Wang, Y Y and 5 more authors..  (2000)  BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures..  Genes & development,    (15):   [PMID:10783165]
6. Guarné, A A, Junop, M S MS and Yang, W W..  (2001)  Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase..  The EMBO journal,    (1):   [PMID:11574484]
7. Yuan, Zi Qiang ZQ and 8 more authors..  (2002)  Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms..  Human mutation,      [PMID:11793469]
8. Hillier, Ladeana W LW and 106 more authors..  (2003)  The DNA sequence of human chromosome 7..  Nature,    (10):   [PMID:12853948]
9. De Vos, Michel M, Hayward, Bruce E BE, Picton, Susan S, Sheridan, Eamonn E and Bonthron, David T DT..  (2004)  Novel PMS2 pseudogenes can conceal recessive mutations causing a distinctive childhood cancer syndrome..  American journal of human genetics,      [PMID:15077197]
10. Worthley, Daniel L DL and 6 more authors..  (2005)  Familial mutations in PMS2 can cause autosomal dominant hereditary nonpolyposis colorectal cancer..  Gastroenterology,      [PMID:15887124]
11. Constantin, Nicoleta N, Dzantiev, Leonid L, Kadyrov, Farid A FA and Modrich, Paul P..  (2005)  Human mismatch repair: reconstitution of a nick-directed bidirectional reaction..  The Journal of biological chemistry,    (2):   [PMID:16188885]
12. Hendriks, Yvonne M C YM and 13 more authors..  (2006)  Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome)..  Gastroenterology,      [PMID:16472587]
13. Clendenning, Mark M and 8 more authors..  (2006)  Long-range PCR facilitates the identification of PMS2-specific mutations..  Human mutation,      [PMID:16619239]
14. and Jiricny, Josef J..  (2006)  MutLalpha: at the cutting edge of mismatch repair..  Cell,    (28):   [PMID:16873053]
15. Kadyrov, Farid A FA, Dzantiev, Leonid L, Constantin, Nicoleta N and Modrich, Paul P..  (2006)  Endonucleolytic function of MutLalpha in human mismatch repair..  Cell,    (28):   [PMID:16873062]
16. Auclair, Jessie J and 12 more authors..  (2007)  Novel biallelic mutations in MSH6 and PMS2 genes: gene conversion as a likely cause of PMS2 gene inactivation..  Human mutation,      [PMID:17557300]
17. and Li, Guo-Min GM..  (2008)  Mechanisms and functions of DNA mismatch repair..  Cell research,      [PMID:18157157]
18. Clendenning, M M and 11 more authors..  (2008)  A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome..  Journal of medical genetics,      [PMID:18178629]
19. Sacho, Elizabeth J EJ, Kadyrov, Farid A FA, Modrich, Paul P, Kunkel, Thomas A TA and Erie, Dorothy A DA..  (2008)  Direct visualization of asymmetric adenine-nucleotide-induced conformational changes in MutL alpha..  Molecular cell,    (18):   [PMID:18206974]
20. Senter, Leigha L and 17 more authors..  (2008)  The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations..  Gastroenterology,      [PMID:18602922]
21. Montazer Haghighi, Mahdi M and 5 more authors..  (2009)  Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer..  International journal of colorectal disease,      [PMID:19479271]
22. Ganster, Christina C and 9 more authors..  (2010)  Functional PMS2 hybrid alleles containing a pseudogene-specific missense variant trace back to a single ancient intrachromosomal recombination event..  Human mutation,      [PMID:20186689]
23. Smogorzewska, Agata A and 10 more authors..  (2010)  A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair..  Molecular cell,    (9):   [PMID:20603073]
24. Borràs, Ester E and 15 more authors..  (2013)  Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants..  Journal of medical genetics,      [PMID:23709753]
25. Drost, Mark M, Koppejan, Hester H and de Wind, Niels N..  (2013)  Inactivation of DNA mismatch repair by variants of uncertain significance in the PMS2 gene..  Human mutation,      [PMID:24027009]
26. van der Klift, Heleen M HM and 24 more authors..  (2016)  Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency Syndrome..  Human mutation,      [PMID:27435373]
27. Arora, Sanjeevani S and 10 more authors..  (2017)  Functional analysis of rare variants in mismatch repair proteins augments results from computation-based predictive methods..  Cancer biology & therapy,    (3):   [PMID:28494185]
28. de Barros, Andrea C AC and 5 more authors..  (2018)  DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway..  Biochimie,      [PMID:29175432]
29. D'Arcy, Brandon M BM, Blount, Jessa J and Prakash, Aishwarya A..  (2019)  Biochemical and structural characterization of two variants of uncertain significance in the PMS2 gene..  Human mutation,      [PMID:30653781]

Calculator