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TKL:Tyrosine kinase-like
PN10 , CAS No.P612882, Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 2

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PN10 , CAS No.P612882, Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 2

Moligand™

PubChem CID: 90448438

Item Number

P612882

Grouped product items
SKU	Size	Availability	Price	Qty
P612882-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$572.90
P612882-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

receptor interacting serine/threonine kinase 1 Inhibitor receptor interacting serine/threonine kinase 2 Inhibitor

Basic Description

Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of receptor interacting serine/threonine kinase 1;Inhibitor of receptor interacting serine/threonine kinase 2

Associated Targets

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 1 Activities

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 1 Activities

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[(7-chloro-1H-indol-3-yl)methyl]-3-[4-[3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylphenyl]butyl]imidazolidine-2,4-dione
INCHI	InChI=1S/C31H27ClN6O2/c1-20-10-11-21(16-22(20)12-13-24-19-33-28-9-5-14-35-38(24)28)6-2-3-15-37-30(39)27(36-31(37)40)17-23-18-34-29-25(23)7-4-8-26(29)32/h4-5,7-11,14,16,18-19,27,34H,2-3,6,15,17H2,1H3,(H,36,40)
InChi Key	ZQSZVECJMJELSV-UHFFFAOYSA-N
Canonical SMILES	O=C1NC(C(=O)N1CCCCc1ccc(c(c1)C#Cc1cnc2n1nccc2)C)Cc1c[nH]c2c1cccc2Cl
Isomeric SMILES	CC1=C(C=C(C=C1)CCCCN2C(=O)C(NC2=O)CC3=CNC4=C3C=CC=C4Cl)C#CC5=CN=C6N5N=CC=C6
PubChem CID	90448438

Database links

PubChem CID	90448438

Certificates

Certificate of Analysis(COA)

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References

1. Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J et al.. (2015) Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.. Cell Rep, 10 (11): (1850-60). [PMID:25801024]

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