Click Here for 5% Off Your First Aladdin Purchase!

Poloxamer 407 - purified, non-ionic, high purity , CAS No.9003-11-6

  • purified, non-ionic
Item Number
P434419
Grouped product items
SKUSizeAvailabilityPrice Qty
P434419-50g
50g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$60.90
P434419-250g
250g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$183.90

Basic Description

SynonymsPoloxalene|9003-11-6|Poloxamer 188|106392-12-5|Poloxamer 407|Pluronic F-68|2-methyloxirane;oxirane|TERGITOL(TM)XH(NONIONIC)|Pluronic L|Pluronic L 122|691397-13-4|Pluronic|F-108|Poloxamer 331|Pluronic L 61|Poloxalkol|Therabloat|Proxanol|Epan 485|Epan 710|E
Specifications & Puritypurified, non-ionic
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application:

as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice;for VLDL secretion assay in mice;to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production  

Names and Identifiers

IUPAC Name 2-methyloxirane;oxirane
INCHI InChI=1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChi Key RVGRUAULSDPKGF-UHFFFAOYSA-N
Canonical SMILES CC1CO1.C1CO1
Isomeric SMILES CC1CO1.C1CO1
Alternate CAS 691397-13-4
PubChem CID 24751

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
E2427402Certificate of AnalysisNov 03, 2023 P434419
K2301427Certificate of AnalysisNov 03, 2023 P434419
K2301428Certificate of AnalysisNov 03, 2023 P434419
K2301429Certificate of AnalysisNov 03, 2023 P434419
K2301462Certificate of AnalysisNov 03, 2023 P434419

Chemical and Physical Properties

Solubilitysoluble, clear, colorless
Refractive Index1.459
Boil Point(°C)> 149 °C
Melt Point(°C)55 - 61 °C

Safety and Hazards(GHS)

Signal Warning

Related Documents

References

1. Céline Durand-Gasselin,Nicolas Sanson,Nicolas Lequeux.  (2011-09-29)  Reversible controlled assembly of thermosensitive polymer-coated gold nanoparticles..  Langmuir : the ACS journal of surfaces and colloids,  27  ((20)): (12329-12335).  [PMID:21902271]
2. Laurien Buitinga,Louise M A Braakman-Jansen,Erik Taal,Mart A F J van de Laar.  (2011-10-04)  A computer Time Trade-Off: a feasible and reliable alternative for the interview Time Trade-Off in rheumatoid arthritis..  Clinical and experimental rheumatology,  29  ((5)): (783-789).  [PMID:21961923]
3. Tsz Chung Lai,Kazunori Kataoka,Glen S Kwon.  (2011-10-18)  Bioreducible polyether-based pDNA ternary polyplexes: balancing particle stability and transfection efficiency..  Colloids and surfaces. B, Biointerfaces,  99  (27-37).  [PMID:22000077]
4. Yanbin Guan,Jiangeng Huang,Lan Zuo,Jiaqiang Xu,Luqin Si,Jun Qiu,Gao Li.  (2011-11-15)  Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism..  Archives of pharmacal research,  34  ((10)): (1719-1728).  [PMID:22076772]
5. Xijun Zhang,Kaiyan Li,Xian Cui,Liangjun Hu,Yunchao Chen.  (2011-12-17)  Combined pluronic P85- and ultrasound contrast agents-mediated gene transfection to HepG2 cells..  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,  31  ((6)): (842-845).  [PMID:22173510]
6. Amit Kumar Mandal,Supratik Sen Mojumdar,Atanu Kumar Das,Kankan Bhattacharyya.  (2012-01-10)  Effect of ionic liquid on diffusion in P123 gel: fluorescence correlation spectroscopy..  Chemphyschem : a European journal of chemical physics and physical chemistry,  13  ((7)): (1942-1948).  [PMID:22223217]
7. D J Bartley,A A Morrison,J Dupuy,Y Bartley,J F Sutra,C Menez,M Alvinerie,F Jackson,L Devin,A Lespine.  (2012-03-21)  Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate..  Veterinary parasitology,  187  ((3-4)): (464-472).  [PMID:22429700]
8. Mi Mi Wan,Wei Gang Lin,Ling Gao,Hui Cheng Gu,Jian Hua Zhu.  (2012-04-18)  Promoting immobilization and catalytic activity of horseradish peroxidase on mesoporous silica through template micelles..  Journal of colloid and interface science,  377  ((1)): (497-503).  [PMID:22507401]
9. V K Zhalimov,A N Sklifas,N I Kukushkin.  (2012-05-19)  [Mechanisms of human plasma proteins adsorption on the surface of perfluorocarbon emulsion stabilized with proxanol 268]..  Biofizika,  57  ((2)): (308-316).  [PMID:22594288]
10. A N Sklifas,V K Zhalimov,A A Temnov,N I Kukushkin.  (2012-05-19)  [Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo studies)]..  Biofizika,  57  ((2)): (317-324).  [PMID:22594289]
11. Marcilio S S Cunha-Filho,Carmen Alvarez-Lorenzo,Ramón Martínez-Pacheco,Mariana Landin.  (2012-05-26)  Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol..  TheScientificWorldJournal,  2012  (126723-126723).  [PMID:22629119]
12. Wei Xu,Yanan Cui,Peixue Ling,Ling-bing Li.  (2012-05-31)  Preparation and evaluation of folate-modified cationic pluronic micelles for poorly soluble anticancer drug..  Drug delivery,  19  ((4)): (208-219).  [PMID:22643055]
13. A Kiwilsza,J Mielcarek,A Pajzderska,J Wąsicki.  (2012-06-09)  Ordered mesoporous silica material SBA-15: loading of new calcium channel blocker--lacidipine..  Journal of microencapsulation,  30  ((1)): (21-27).  [PMID:22676483]
14. Jun Song,Wei Zhen,Zonghao Li,Yuanpei Lian,Yaling Yang.  (2012-07-07)  Ultrasonic-assisted cloud point extraction for determination of nickel in water samples by flame atomic absorption spectrometry..  Water science and technology : a journal of the International Association on Water Pollution Research,  66  ((4)): (792-798).  [PMID:22766868]
15. Huihui Ma,Fengtian Mu,Shujuan Fan,Xiao Zhou,Qiong Jia.  (2012-08-30)  Development of a cloud point extraction method for the determination of phenolic compounds in environmental water samples coupled with high-performance liquid chromatography..  Journal of separation science,  35  ((18)): (2484-2490).  [PMID:22930563]
16. Houjian Gong,Guiying Xu,Teng Liu,Long Xu,Xueru Zhai,Jian Zhang,Xin Lv.  (2012-09-08)  Aggregation behaviors of PEO-PPO-ph-PPO-PEO and PPO-PEO-ph-PEO-PPO at an air/water interface: experimental study and molecular dynamics simulation..  Langmuir : the ACS journal of surfaces and colloids,  28  ((38)): (13590-13600).  [PMID:22954368]
17. Irshad A Wani,Sarvari Khatoon,Aparna Ganguly,Jahangeer Ahmed,Tokeer Ahmad,Nikhat Manzoor.  (2012-09-27)  Structural characterization and antimicrobial properties of silver nanoparticles prepared by inverse microemulsion method..  Colloids and surfaces. B, Biointerfaces,  101  (243-250).  [PMID:23010026]
18. Jianan Shen,Huiping Sun,Pengfei Xu,Qi Yin,Zhiwen Zhang,Siling Wang,Haijun Yu,Yaping Li.  (2012-11-14)  Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles..  Biomaterials,  34  ((5)): (1581-1590).  [PMID:23146437]
19. Neeta Jain-Gupta,Araceli Contreras-Rodriguez,Ramesh Vemulapalli,Sharon G Witonsky,Stephen M Boyle,Nammalwar Sriranganathan.  (2012-11-21)  Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine against Brucella melitensis challenge in mice..  FEMS immunology and medical microbiology,  66  ((3)): (436-444).  [PMID:23163875]
20. Wanhua Feng,Simon Swift,Naresh Singhal.  (2013-01-29)  Effects of surfactants on cell surface tension parameters and hydrophobicity of Pseudomonas putida 852 and Rhodococcus erythropolis 3586..  Colloids and surfaces. B, Biointerfaces,  105  (43-50).  [PMID:23352946]
21. Susruta Samanta,Danilo Roccatano.  (2013-02-28)  Interaction of Curcumin with PEO-PPO-PEO block copolymers: a molecular dynamics study..  The journal of physical chemistry. B,  117  ((11)): (3250-3257).  [PMID:23441964]
22. Zunfang Hu,Longqian Xu,Xianghua Wen.  (2013-04-17)  Mesoporous silicas synthesis and application for lignin peroxidase immobilization by covalent binding method..  Journal of environmental sciences (China),  25  ((1)): (181-187).  [PMID:23586313]
23. Nae-Gyune Rim,Erin G Roberts,Davoud Ebrahimi,Nina Dinjaski,Matthew M Jacobsen,Zaira Martín-Moldes,Markus J Buehler,David L Kaplan,Joyce Y Wong.  (2017-10-03)  Predicting Silk Fiber Mechanical Properties through Multiscale Simulation and Protein Design..  ACS biomaterials science & engineering,  ((8)): (1542-1556).  [PMID:28966980]
24. Ron S Gejman,Heather F Jones,Martin G Klatt,Aaron Y Chang,Claire Y Oh,Smita S Chandran,Tatiana Korontsvit,Viktoriya Zakahleva,Tao Dao,Christopher A Klebanoff,David A Scheinberg.  (2020-03-19)  Identification of the Targets of T-cell Receptor Therapeutic Agents and Cells by Use of a High-Throughput Genetic Platform..  Cancer immunology research,  ((5)): (672-684).  [PMID:32184297]
25. Hua Qing, Reina Desrouleaux, Kavita Israni-Winger, Yann S Mineur, Nia Fogelman, Cuiling Zhang, Saleh Rashed, Noah W Palm, Rajita Sinha, Marina R Picciotto, Rachel J Perry, Andrew Wang,.  (2020-07-02)  Origin and Function of Stress-Induced IL-6 in Murine Models..  Cell,  182  ((2)): ( 372-387 ).  [PMID:32610084]
26. Camila S Freitas,João A Oliveira-da-Silva,Daniela P Lage,Rafaella R Costa,Débora V C Mendonça,Vívian T Martins,Thiago A R Reis,Luciana M R Antinarelli,Amanda S Machado,Grasiele S V Tavares,Fernanda F Ramos,Vinicio T S Coelho,Rory C F Brito,Fernanda Ludolf,Miguel A Chávez-Fumagalli,Bruno M Roatt,Gabriela S Ramos,Jennifer Munkert,Flaviano M Ottoni,Priscilla R V Campana,Maria V Humbert,Elaine S Coimbra,Fernão C Braga,Rodrigo M Pádua,Eduardo A F Coelho.  (2020-11-17)  Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis..  Parasitology research,  120  ((1)): (321-335).  [PMID:33191446]
27. Jianan Shen,Qi Yin,Lingli Chen,Zhiwen Zhang,Yaping Li.  (2012-08-23)  Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer..  Biomaterials,  33  ((33)): (8613-8624).  [PMID:22910221]
28. 潘振星.  (2024)  Rotor-based image-guided therapy of glioblastoma.  Journal of Controlled Release,  (368): (650–662).  [PMID:]

Solution Calculators