Biocompatible, amphiphilicblockcopolymer composed of a hydrophilic PEGblockand a hydrophobic Poly(lactide-co-glycolide) (PLGA)block, functionalized with a terminal carboxylic acid. These materials have been used in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymerblock. Additionally, the ratio of lactide to glycolide can be tuned to control rate of degradation. Carboxylic acid termination allows for facile further chemical modification of these materials.
1.Miles A Miller, Yao-Rong Zheng, Suresh Gadde, Christina Pfirschke, Harshal Zope, Camilla Engblom, Rainer H Kohler, Yoshiko Iwamoto, Katherine S Yang, Bjorn Askevold, Nagesh Kolishetti, Mikael Pittet, Stephen J Lippard, Omid C Farokhzad, Ralph Weissleder,. (2015-10-28) Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.. Nature communications, ( 8692-8692 ). [PMID:26503691]
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