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Polyglycine - mol wt 500-5,000, high purity , CAS No.25718-94-9, Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D;sodium-coupled neutral amino acid transporter 4

Moligand™
mol wt 500-5,000

CAS#: 25718-94-9
Formula: C₂H₅NO₂
Molecular Weight: 75.07
EC Number: 200-272-2,654-407-9
MDL number: MFCD00166375
PubChem CID: 750

Item Number

P477807

Grouped product items
SKU	Size	Availability	Price	Qty
P477807-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,211.90

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GluN1 Agonist GluN2A Agonist GluN2B Agonist GluN2C Agonist GluN2D Agonist sodium-coupled neutral amino acid transporter 4

Basic Description

Synonyms	glycine\|2-Aminoacetic acid\|56-40-6\|aminoacetic acid\|Glycocoll\|Aminoethanoic acid\|Glycolixir\|H-Gly-OH\|Glycosthene\|Glicoamin\|Aciport\|Padil\|Hampshire glycine\|L-Glycine\|Amitone\|Leimzucker\|Aminoazijnzuur\|Acetic acid, amino-\|Glycine, non-medical\|Sucre de gelati
Specifications & Purity	Moligand™, mol wt 500-5,000
Biochemical and Physiological Mechanisms	Polyglycine exists in two forms, namely the polyglycine I (PGI) with anti-parallel β-sheet structure and polyglycine II (PGII) with extended 31-helix. It is a most flexible polypeptide with minimal steric hindrance and its solubility increases in the pres
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GluN1;Agonist of GluN2A;Agonist of GluN2B;Agonist of GluN2C;Agonist of GluN2D;sodium-coupled neutral amino acid transporter 4
Product Description	Description Polyglycine has been used as an external intensity standard for measuring cross polarization (CP) nuclear magnetic resonance (NMR) spectrum measurements and ion mobility mass spectrometry. It is suitable for use as a model for UV resonance Raman spectroscopy studies.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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ELANE Tclin Neutrophil elastase 0 Activities

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ELN Tbio Elastin 0 Activities

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EGFR Tclin Epidermal growth factor receptor 0 Activities

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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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CHRM4 Tclin Muscarinic acetylcholine receptor M4 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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AKR1B1 Tclin Aldose reductase 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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F2 Tclin Prothrombin 0 Activities

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EDNRA Tclin Endothelin-1 receptor 0 Activities

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GLRA1 Tclin Glycine receptor subunit alpha-1 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

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GPRC6A Tchem G-protein coupled receptor family C group 6 member A 0 Activities

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OPRD1 Tclin Delta-type opioid receptor 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

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TACR1 Tclin Substance-P receptor 0 Activities

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OR51E2 Tchem Olfactory receptor 51E2 2 Activities

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NOS1 Tchem Nitric oxide synthase, brain 0 Activities

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Names and Identifiers

IUPAC Name	2-aminoacetic acid
INCHI	InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChi Key	DHMQDGOQFOQNFH-UHFFFAOYSA-N
Canonical SMILES	C(C(=O)O)N
Isomeric SMILES	C(C(=O)O)N
Alternate CAS	18875-39-3,56-40-6,25718-94-9,7490-95-1 (hydrochloride (2:1))
PubChem CID	750
NSC Number	25936
MeSH Entry Terms	Acid, Aminoacetic;Aminoacetic Acid;Calcium Salt Glycine;Cobalt Salt Glycine;Copper Salt Glycine;Glycine;Glycine Carbonate (1:1), Monosodium Salt;Glycine Carbonate (2:1), Monolithium Salt;Glycine Carbonate (2:1), Monopotassium Salt;Glycine Carbonate (2:1),
Molecular Weight	75.07

Database links

ChEMBL Ligand	CHEMBL773
PubChem CID	750
RCSB PDB Ligand	GLY
DrugCentral Ligand	1319
GPCRdb Ligand	[³H]glycine

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Flash Point(°F)	Not applicable
Flash Point(°C)	Not applicable
Melt Point(°C)	300℃

Safety and Hazards(GHS)

RIDADR	NONH for all modes of transport

References

1. Felix Hernández,Alberto Gómez-Ramos,Paloma Goñi-Oliver,Jesús Avila,Nieves Villanueva. (2008-08-06) Role of polyglycine repeats in the regulation of glycogen synthase kinase activity.. Protein and peptide letters, 15 ((6)): (586-589). [PMID:18680453]
2. Marco Lalle,Carlo Bavassano,Federica Fratini,Serena Cecchetti,Prisca Boisguerin,Marco Crescenzi,Edoardo Pozio. (2009-09-08) Involvement of 14-3-3 protein post-translational modifications in Giardia duodenalis encystation.. International journal for parasitology, 40 ((2)): (201-213). [PMID:19733174]
3. Giorgio Schiró,Chiara Caronna,Francesca Natali,Antonio Cupane. (2010-01-14) Direct evidence of the amino acid side chain and backbone contributions to protein anharmonicity.. Journal of the American Chemical Society, 132 ((4)): (1371-1376). [PMID:20067251]
4. Kiran Kumar Morishetti,Betty De Suan Huang,Jessica Marney Yates,Jianhua Ren. (2010-01-29) Gas-phase acidities of cysteine-polyglycine peptides: the effect of the cysteine position.. Journal of the American Society for Mass Spectrometry, 21 ((4)): (603-614). [PMID:20106677]
5. Koji Ikegami,Mitsutoshi Setou. (2010-03-02) Unique post-translational modifications in specialized microtubule architecture.. Cell structure and function, 35 ((1)): (15-22). [PMID:20190462]
6. Sergei Bykov,Sanford Asher. (2010-04-27) Raman studies of solution polyglycine conformations.. The journal of physical chemistry. B, 114 ((19)): (6636-6641). [PMID:20415491]
7. Marija Mojsin,Natasa Kovacevic-Grujicic,Aleksandar Krstic,Jelena Popovic,Milena Milivojevic,Milena Stevanovic. (2010-05-25) Comparative analysis of SOX3 protein orthologs: Expansion of homopolymeric amino acid tracts during vertebrate evolution.. Biochemical genetics, 48 ((7-8)): (612-623). [PMID:20495863]
8. Ohki Kambara,Atsuo Tamura,Takashi Uchino,Kohji Yamamoto,Keisuke Tominaga. (2010-06-03) Terahertz time-domain spectroscopy of poly-L-lysine.. Biopolymers, 93 ((8)): (735-739). [PMID:20517954]
9. Roman M Balabin. (2010-06-25) Communications: Is quantum chemical treatment of biopolymers accurate? Intramolecular basis set superposition error (BSSE).. The Journal of chemical physics, 132 ((23)): (231101-231101). [PMID:20572680]
10. Giorgio Schiró,Chiara Caronna,Francesca Natali,Antonio Cupane. (2010-07-30) Molecular origin and hydration dependence of protein anharmonicity: an elastic neutron scattering study.. Physical chemistry chemical physics : PCCP, 12 ((35)): (10215-10220). [PMID:20668739]
11. Guillaume Herlem,Rabah Zeggari,Jean-Yves Rauch,Sandrine Monney,Freddy Torrealba Anzola,Yves Guillaume,Claire André,Tijani Gharbi. (2010-08-06) One-pot electrosynthesis of polyglycine-like thin film on platinum electrodes as transducer for solid state pH measurements.. Talanta, 82 ((1)): (417-421). [PMID:20685487]
12. Nicola J Rutherford,Nicole A Finch,Mariely DeJesus-Hernandez,Richard J P Crook,Catherine Lomen-Hoerth,Zbigniew K Wszolek,Ryan J Uitti,Neill R Graff-Radford,Rosa Rademakers. (2010-11-16) Pathogenicity of exonic indels in fused in sarcoma in amyotrophic lateral sclerosis.. Neurobiology of aging, 33 ((2)): (424-424). [PMID:21074900]
13. Joshua A Plumley,Midas I-Hsien Tsai,J J Dannenberg. (2011-01-26) Aggregation of capped hexaglycine strands into hydrogen-bonding motifs representative of pleated and rippled β-sheets, collagen, and polyglycine I and II crystal structures. A density functional theory study.. The journal of physical chemistry. B, 115 ((6)): (1562-1570). [PMID:21261311]
14. O Petru Balaj,David Semrouni,Vincent Steinmetz,Edith Nicol,Carine Clavaguéra,Gilles Ohanessian. (2012-03-06) Structure of sodiated polyglycines.. Chemistry (Weinheim an der Bergstrasse, Germany), 18 ((15)): (4583-4592). [PMID:22389058]
15. Aykut Erbaş,Roland R Netz. (2013-03-27) Confinement-dependent friction in peptide bundles.. Biophysical journal, 104 ((6)): (1285-1295). [PMID:23528088]
16. Karen L Ostberg,Amanda J DeRocco,Shreni D Mistry,Mary Kathryne Dickinson,Cynthia Nau Cornelissen. (2013-07-10) Conserved regions of gonococcal TbpB are critical for surface exposure and transferrin iron utilization.. Infection and immunity, 81 ((9)): (3442-3450). [PMID:23836816]
17. Milagros Castellanos,Rebeca Pérez,Alicia Rodríguez-Huete,Esther Grueso,José M Almendral,Mauricio G Mateu. (2013-07-24) A slender tract of glycine residues is required for translocation of the VP2 protein N-terminal domain through the parvovirus MVM capsid channel to initiate infection.. The Biochemical journal, 455 ((1)): (87-94). [PMID:23875612]
18. A M Yu,H L Zhang,H Y Chen. (1997-08-01) Catalytic oxidation of uric acid at the polyglycine chemically modified electrode and its trace determination.. The Analyst, 122 ((8)): (839-841). [PMID:9338990]
19. Denes Kovacs,Evangelos Vassos,Xiehe Liu,Xueli Sun,Junmei Hu,Gerome Breen,Peter Tompa,David A Collier,Tao Li. (2009-03-06) The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals.. Psychoneuroendocrinology, 34 ((6)): (947-952). [PMID:19261388]
20. Sirish Kaushik Lakkaraju,Wonmuk Hwang. (2009-04-28) Critical buckling length versus persistence length: what governs biofilament conformation?. Physical review letters, 102 ((11)): (118102-118102). [PMID:19392240]
21. Li Guo,Donghui Zhang. (2009-12-03) Cyclic poly(alpha-peptoid)s and their block copolymers from N-heterocyclic carbene-mediated ring-opening polymerizations of N-substituted N-carboxylanhydrides.. Journal of the American Chemical Society, 131 ((50)): (18072-18074). [PMID:19950948]
22. Anna Maria Ferrari,Bartolomeo Civalleri,Roberto Dovesi. (2010-01-09) Ab initio periodic study of the conformational behavior of glycine helical homopeptides.. Journal of computational chemistry, 31 ((8)): (1777-1784). [PMID:20058227]
23. Dahiyana Cristancho,Jorge M Seminario. (2010-02-16) Polypeptides in alpha-helix conformation perform as diodes.. The Journal of chemical physics, 132 ((6)): (065102-065102). [PMID:20151758]
24. David Semrouni,O Petru Balaj,Florent Calvo,Catarina F Correia,Carine Clavaguéra,Gilles Ohanessian. (2010-03-02) Structure of sodiated octa-glycine: IRMPD spectroscopy and molecular modeling.. Journal of the American Society for Mass Spectrometry, 21 ((5)): (728-738). [PMID:20189824]
25. Florian Albrieux,Florent Calvo,Fabien Chirot,Aleksey Vorobyev,Yury O Tsybin,Valéria Lepère,Rodolphe Antoine,Jérôme Lemoine,Philippe Dugourd. (2010-06-11) Conformation of polyalanine and polyglycine dications in the gas phase: insight from ion mobility spectrometry and replica-exchange molecular dynamics.. The journal of physical chemistry. A, 114 ((25)): (6888-6896). [PMID:20533847]
26. Amelia Guadalupe-Grau,Francisco Germán Rodríguez-González,Jesús Gustavo Ponce-González,Cecilia Dorado,Hugo Olmedillas,Teresa Fuentes,Jorge Pérez-Gómez,Joaquín Sanchís-Moysi,Bonifacio Nicolás Díaz-Chico,José A L Calbet. (2010-07-17) Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.. PloS one, 5 ((7)): (e11529-e11529). [PMID:20634949]
27. Edson P Bellido,Jorge M Seminario. (2011-11-29) Harmonic force field for nitro compounds.. Journal of molecular modeling, 18 ((6)): (2805-2811). [PMID:22119786]
28. Nobuhiro Koyama,Yuriko Tokura,Daniela Münch,Hans-Georg Sahl,Tanja Schneider,Yoshio Shibagaki,Haruo Ikeda,Hiroshi Tomoda. (2012-11-21) The nonantibiotic small molecule cyslabdan enhances the potency of β-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.. PloS one, 7 ((11)): (e48981-e48981). [PMID:23166602]

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