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Polymyxin B solution - 20 mg/mL in H2O, high purity , CAS No.1405-20-5

8 Citations

20 mg/mL in H2O

CAS#: 1405-20-5
Formula: C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight: 1301.6
PubChem CID: 5702105

Item Number

P432050

Grouped product items
SKU	Size	Availability	Price	Qty
P432050-10ml	10ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$926.90
P432050-125ml	125ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$10,747.90

Basic Description

Synonyms	1405-20-5, 4135-11-9 (free base) \| AKOS015895662 \| HMS2092A07 \| BCP12700 \| SR-05000002074-1 \| HFMDLUQUEXNBOP-UHFFFAOYSA-N \| HMS1920J04 \| A807660 \| CCG-39724 \| sufuric acid \| HMS502E14 \| N-[4-Amino-1-({1-[(4-amino-1-oxo-1-{[6,9,18-tris(2-aminoethyl)-15-ben
Specifications & Purity	20 mg/mL in H2O
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	General Description Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa . Application Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Other Notes Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.

Names and Identifiers

IUPAC Name	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
INCHI	InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
InChi Key	HFMDLUQUEXNBOP-UHFFFAOYSA-N
Canonical SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Isomeric SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
RTECS	TR1150000
PubChem CID	5702105
Molecular Weight	1301.6

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	H2O: soluble 20mg/mL
Specific Rotation[α]	-80 ° (C=2, H2O)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
RTECS	TR1150000
Merck Index	7573

FAQs and Articles

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Antimicrobial Peptides: A Promising Field in Antibiotic Research

Categories: Technical articles

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Antibiotics Natural products Immunology Antimicrobial ligands Peptides WHO Essential Medicine ligands Human endogenous peptides Antimicrobial peptides RAMPs Biology of Cells

Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652]
2. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
3. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
4. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
5. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
6. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
7. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
8. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]
9. Bailong Tao, Chuanchuan Lin, Zhang Yuan, Ye He, Maowen Chen, Ke Li, Jingwei Hu, Yulu Yang, Zengzilu Xia, Kaiyong Cai. (2021) Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing. CHEMICAL ENGINEERING JOURNAL, 403 (126182). [PMID:]

References

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46. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
47. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
48. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
49. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
50. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
51. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
52. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]
53. Bailong Tao, Chuanchuan Lin, Zhang Yuan, Ye He, Maowen Chen, Ke Li, Jingwei Hu, Yulu Yang, Zengzilu Xia, Kaiyong Cai. (2021) Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing. CHEMICAL ENGINEERING JOURNAL, 403 (126182). [PMID:]

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