Skip to the beginning of the images gallery

Polymyxin B sulfate - USP grade，≥6,000 USP units/mg, high purity , CAS No.1405-20-5

8 Citations

pharmaceutical grade

6,000 USP units/mg

CAS#: 1405-20-5
Formula: C₅₆H₁₀₀N₁₆O₁₇S
Molecular Weight: 1301.6
MDL number: MFCD00131991
PubChem CID: 5702105
PubChem SID: 488195591

Item Number

P105490

Grouped product items
SKU	Size	Availability	Price
P105490-1g	1g	In stock	$49.90
P105490-5g	5g	In stock	$171.90
P105490-25g	25g	In stock	$602.90

Cationic surfactant antibiotic agent

View related series

Anti-infection Antibiotics Bacterial polypeptide

Basic Description

Synonyms	AKOS015895662 \| HMS2092A07 \| BCP12700 \| HFMDLUQUEXNBOP-UHFFFAOYSA-N \| HMS1920J04 \| CCG-39724 \| sufuric acid \| HMS502E14 \| SPECTRUM1500492 \| KS-1428 \| NCGC00094763-01 \| NSC757278 \| Pharmakon1600-01500492 \| Aerosporin \| NCGC00094763-02 \| MFCD00131991 \| s139
Specifications & Purity	pharmaceutical grade, 6,000 USP units/mg
Biochemical and Physiological Mechanisms	Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate bind
Storage Temp	Store at 2-8°C,Protected from light
Shipped In	Wet ice
Grade	pharmaceutical grade
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Chemical structure: peptide Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Polymyxin B sulfate salt has been used: • in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin • in the analysis of the isolates • in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)

Names and Identifiers

Pubchem Sid	488195591
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195591
IUPAC Name	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
INCHI	InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
InChi Key	HFMDLUQUEXNBOP-UHFFFAOYSA-N
Canonical SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Isomeric SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
RTECS	TR1150000
PubChem CID	5702105
Molecular Weight	1301.6

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
G2310743	Certificate of Analysis	Jun 19, 2023	P105490
G2310744	Certificate of Analysis	Jun 19, 2023	P105490
G2310779	Certificate of Analysis	Jun 19, 2023	P105490
C2307892	Certificate of Analysis	Feb 03, 2023	P105490
C2307894	Certificate of Analysis	Feb 03, 2023	P105490
C2308036	Certificate of Analysis	Feb 03, 2023	P105490
C2308038	Certificate of Analysis	Feb 03, 2023	P105490
C2308039	Certificate of Analysis	Feb 03, 2023	P105490
C2308049	Certificate of Analysis	Feb 03, 2023	P105490
H2209687	Certificate of Analysis	Jul 23, 2022	P105490
H2209688	Certificate of Analysis	Jul 23, 2022	P105490
K2217178	Certificate of Analysis	Jul 23, 2022	P105490

Show more⌵

Chemical and Physical Properties

Solubility	Soluble in water at 50mg/ml/n
Sensitivity	Light & heat & Moisture sensitive.
Specific Rotation[α]	-80 ° (C=2, H2O)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
RTECS	TR1150000
Merck Index	7573

Alternative Products

FAQs and Articles

FAQ

Antimicrobial Peptides: A Promising Field in Antibiotic Research

Categories: Technical articles

Tags:

Antibiotics Natural products Immunology Antimicrobial ligands Peptides WHO Essential Medicine ligands Human endogenous peptides Antimicrobial peptides RAMPs Biology of Cells

Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652]
2. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
3. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
4. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
5. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
6. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
7. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
8. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]

References

1. M E Evans,D J Feola,R P Rapp. (1999-09-24) Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria.. The Annals of pharmacotherapy, 33 ((9)): (960-967). [PMID:10492501]
2. Travis J Wiles,Bijaya K Dhakal,Danelle S Eto,Matthew A Mulvey. (2008-02-01) Inactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins.. Molecular biology of the cell, 19 ((4)): (1427-1438). [PMID:18234841]
3. Sara N Vallerie,Masato Furuhashi,Raquel Fucho,Gökhan S Hotamisligil. (2008-09-06) A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity.. PloS one, 3 ((9)): (e3151-e3151). [PMID:18773087]
4. Mariana G Corigliano,Andrea Maglioco,Melina Laguía Becher,Alejandra Goldman,Valentina Martín,Sergio O Angel,Marina Clemente. (2011-06-28) Plant Hsp90 proteins interact with B-cells and stimulate their proliferation.. PloS one, 6 ((6)): (e21231-e21231). [PMID:21701588]
5. Silpak Biswas,Jean-Michel Brunel,Jean-Christophe Dubus,Martine Reynaud-Gaubert,Jean-Marc Rolain. (2012-10-04) Colistin: an update on the antibiotic of the 21st century.. Expert review of anti-infective therapy, 10 ((8)): (917-934). [PMID:23030331]
6. Lucía Fernández,Carolina Alvarez-Ortega,Irith Wiegand,Jorge Olivares,Dana Kocíncová,Joseph S Lam,José Luis Martínez,Robert E W Hancock. (2012-10-17) Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.. Antimicrobial agents and chemotherapy, 57 ((1)): (110-119). [PMID:23070157]
7. Lee Williams,Yogangi Malhotra,Barbra Murante,Susan Laverty,Steve Cook,David Topa,Dwight Hardy,Hongyue Wang,Francis Gigliotti. (2012-10-25) A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children.. The Journal of pediatrics, 162 ((4)): (857-861). [PMID:23092529]
8. Hiroyuki Hirasawa,Shigeto Oda,Masataka Nakamura,Eizo Watanabe,Hidetoshi Shiga,Kenichi Matsuda. (2012-10-26) Continuous hemodiafiltration with a cytokine-adsorbing hemofilter for sepsis.. Blood purification, 34 ((2)): (164-170). [PMID:23095416]
9. Helio S Sader,Paul R Rhomberg,Robert K Flamm,Ronald N Jones. (2012-10-30) Use of a surfactant (polysorbate 80) to improve MIC susceptibility testing results for polymyxin B and colistin.. Diagnostic microbiology and infectious disease, 74 ((4)): (412-414). [PMID:23102558]
10. Verónica López,José M Ricart,Inmaculada López,José M Martín,Davide Marton,Carmen Ortega,Salvador Costa. (2012-11-06) Vascular malformation of the glans penis successfully treated with Nd:YAG laser.. Dermatology online journal, 18 ((10)): (16-16). [PMID:23122023]
11. L M Dijksman,D Roos,M F Gerhards,J G P Tijssen,D J Gouma,M G W Dijkgraaf. (2012-11-07) Cost-effectiveness of perioperative selective decontamination of the digestive tract versus placebo in elective gastrointestinal surgery.. Digestive surgery, 29 ((5)): (384-390). [PMID:23128405]
12. Ana M Sandri,Cornelia B Landersdorfer,Jovan Jacob,Márcio M Boniatti,Micheline G Dalarosa,Diego R Falci,Tainá F Behle,David Saitovitch,Jiping Wang,Alan Forrest,Roger L Nation,Alexandre P Zavascki,Jian Li. (2012-11-28) Pharmacokinetics of polymyxin B in patients on continuous venovenous haemodialysis.. The Journal of antimicrobial chemotherapy, 68 ((3)): (674-677). [PMID:23179561]
13. Lee Sun New,Tze Peng Lim,Jing Wen Oh,Gavin Jia Sheng Cheah,Andrea L Kwa,Eric Chun Yong Chan. (2012-11-28) Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin.. Analytical and bioanalytical chemistry, 405 ((4)): (1407-1415). [PMID:23180085]
14. Martti Vaara,Timo Vaara. (2012-11-28) The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells.. International journal of antimicrobial agents, 41 ((3)): (292-293). [PMID:23182536]
15. Marco M Domingues,Rita G Inácio,José M Raimundo,Miguel Martins,Miguel A R B Castanho,Nuno C Santos. (2012-11-30) Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems.. Biopolymers, 98 ((4)): (338-344). [PMID:23193598]
16. Paul Schaefer,Reginald F Baugh. (2012-12-04) Acute otitis externa: an update.. American family physician, 86 ((11)): (1055-1061). [PMID:23198673]
17. Naoki Sawa,Yoshibumi Ubara,Keiichi Sumida,Rikako Hiramatsu,Eiko Hasegawa,Masayuki Yamanouchi,Junichi Hoshino,Tatsuya Suwabe,Naoyuki Uchida,Atsushi Wake,Shuichi Taniguchi,Kenmei Takaichi. (2012-12-21) Direct hemoperfusion with a polymyxin B column versus vasopressin for gram negative septic shock: a matched cohort study of the effect on survival.. Clinical nephrology, 79 ((6)): (463-470). [PMID:23253903]
18. Chunlei Zhu,Qiong Yang,Fengting Lv,Libing Liu,Shu Wang. (2013-01-03) Conjugated polymer-coated bacteria for multimodal intracellular and extracellular anticancer activity.. Advanced materials (Deerfield Beach, Fla.), 25 ((8)): (1203-1208). [PMID:23280674]
19. Marcelo M Mostardeiro,Carlos A P Pereira,Alexandre R Marra,Jose O M Pestana,Luis Fernando A Camargo. (2013-01-09) Nephrotoxicity and efficacy assessment of polymyxin use in 92 transplant patients.. Antimicrobial agents and chemotherapy, 57 ((3)): (1442-1446). [PMID:23295926]
20. H Deborah Chen,Mollie W Jewett,Eduardo A Groisman. (2013-01-10) An allele of an ancestral transcription factor dependent on a horizontally acquired gene product.. PLoS genetics, 8 ((12)): (e1003060-e1003060). [PMID:23300460]
21. Bing Zhai,Xiaorong Lin. (2013-01-15) Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo.. International journal of antimicrobial agents, 41 ((3)): (250-254). [PMID:23313397]
22. Shyamasree De Majumdar,Mark Veleba,Sarah Finn,Séamus Fanning,Thamarai Schneiders. (2013-01-16) Elucidating the regulon of multidrug resistance regulator RarA in Klebsiella pneumoniae.. Antimicrobial agents and chemotherapy, 57 ((4)): (1603-1609). [PMID:23318802]
23. A Bonura,S Corinti,E Schiavi,D Giacomazza,F Gianguzza,G Di Felice,P Colombo. (2013-01-22) The major allergen of the Parietaria pollen contains an LPS-binding region with immuno-modulatory activity.. Allergy, 68 ((3)): (297-303). [PMID:23330732]
24. Elizabeth M Grossman,Shivani Nanda,Jennifer R S Gordon,Meghan Dubina,Alfred W Rademaker,Dennis P West,Peter A Lio. (2013-02-05) Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment.. Journal of drugs in dermatology : JDD, 11 ((12)): (1490-1492). [PMID:23377521]
25. Kensuke Nakamura,Kent Doi,Ryota Inokuchi,Tatsuma Fukuda,Takahiro Hiruma,Takeshi Ishii,Susumu Nakajima,Eisei Noiri,Naoki Yahagi. (2013-02-13) Endotoxin adsorption by polymyxin B column or intraaortic balloon pumping use for severe septic cardiomyopathy.. The American journal of emergency medicine, 31 ((5)): (893-893). [PMID:23399331]
26. Saurabh Piparsania,Nitin Rajput,Ganesh Bhatambare. (2013-02-23) Intraventricular polymyxin B for the treatment of neonatal meningo-ventriculitis caused by multi-resistant Acinetobacter baumannii--case report and review of literature.. The Turkish journal of pediatrics, 54 ((5)): (548-554). [PMID:23427525]
27. Wei Wang,Guoguang Zhang,Jinmei Zou. (2013-02-27) The interaction of polysaccharide from Auricularia polytricha with quantum dots and the protection of plasmid DNA from damage.. Applied biochemistry and biotechnology, 169 ((8)): (2263-2272). [PMID:23440638]
28. Jung-Whan Chon,Hyunsook Kim,Jin-Hyeok Yim,Jun-Ho Park,Moo-Sang Kim,Kun-Ho Seo. (2013-03-12) Development of a selective enrichment broth supplemented with bacteriological charcoal and a high concentration of polymyxin B for the detection of Campylobacter jejuni and Campylobacter coli in chicken carcass rinses.. International journal of food microbiology, 162 ((3)): (308-310). [PMID:23474610]
29. Nahoko Sato,Keisuke Kojima,Yuko Horio,Eisuke Goto,Aiko Masunaga,Hidenori Ichiyasu,Hirotsugu Kohrogi. (2013-04-03) Successful treatment of severe amiodarone pulmonary toxicity with polymyxin B-immobilized fiber column direct hemoperfusion.. Chest, 143 ((4)): (1146-1150). [PMID:23546489]
30. Daisuke Arai,Koichi Fukunaga,Kentaro Fujii,Ho Namkoong,Mizuha Haraguchi,Yohei Funatsu,Katsuhiko Naoki,Sadatomo Tasaka,Tomoko Betsuyaku. (2013-06-19) [Case report; A case of acute respiratory failure following influenza virus infection successfully treated by direct hemoperfusion using a polymyxin B immobilized fiber column].. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102 ((2)): (429-432). [PMID:23767322]
31. Andrew Goodyear,Linda Strange,Drew A Rholl,Joy Silisouk,David A B Dance,Herbert P Schweizer,Steven Dow. (2013-09-26) An improved selective culture medium enhances the isolation of Burkholderia pseudomallei from contaminated specimens.. The American journal of tropical medicine and hygiene, 89 ((5)): (973-982). [PMID:24062483]
32. Brian T Ho,Marek Basler,John J Mekalanos. (2013-10-12) Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer.. Science (New York, N.Y.), 342 ((6155)): (250-253). [PMID:24115441]
33. Masao Iwagami,Hideo Yasunaga,Kent Doi,Hiromasa Horiguchi,Kiyohide Fushimi,Takehiro Matsubara,Naoki Yahagi,Eisei Noiri. (2013-12-25) Postoperative polymyxin B hemoperfusion and mortality in patients with abdominal septic shock: a propensity-matched analysis.. Critical care medicine, 42 ((5)): (1187-1193). [PMID:24365858]
34. Dinna N Cruz. (2014-04-17) Polymyxin B hemoperfusion: matching the cure to the disease.. Critical care medicine, 42 ((5)): (1309-1310). [PMID:24736351]
35. Gary C Port,Luis A Vega,Andrew B Nylander,Michael G Caparon. (2014-05-06) Streptococcus pyogenes polymyxin B-resistant mutants display enhanced ExPortal integrity.. Journal of bacteriology, 196 ((14)): (2563-2577). [PMID:24794568]
36. Mitsuru Ishizuka,Kazuma Tago,Keiichi Kubota. (2014-06-16) Impact of prothrombin time-International Normalized Ratio on outcome of patients with septic shock receiving polymyxin B cartridge hemoperfusion.. Surgery, 156 ((1)): (168-175). [PMID:24929766]
37. T W Cullen,W B Schofield,N A Barry,E E Putnam,E A Rundell,M S Trent,P H Degnan,C J Booth,H Yu,A L Goodman. (2015-01-13) Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation.. Science (New York, N.Y.), 347 ((6218)): (170-175). [PMID:25574022]
38. Johnny X Huang,Mark A T Blaskovich,Ruby Pelingon,Soumya Ramu,Angela Kavanagh,Alysha G Elliott,Mark S Butler,A Bruce Montgomery,Matthew A Cooper. (2015-07-15) Mucin Binding Reduces Colistin Antimicrobial Activity.. Antimicrobial agents and chemotherapy, 59 ((10)): (5925-5931). [PMID:26169405]
39. Amit Kumar,Mukesh Mahajan,Bhanupriya Awasthi,Anshika Tandon,Munesh Kumar Harioudh,Sonal Shree,Pratiksha Singh,Praveen Kumar Shukla,Ravishankar Ramachandran,Kalyan Mitra,Surajit Bhattacharjya,Jimut Kanti Ghosh. (2017-01-05) Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities.. Scientific reports, 7 (39925-39925). [PMID:28051162]
40. Martti Vaara,Timo Vaara,Jonathan M Tyrrell. (2017-03-17) Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.. Peptides, 91 (8-12). [PMID:28300674]
41. Martti Vaara,Timo Vaara,Carina Vingsbo Lundberg. (2017-11-18) Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis.. The Journal of antimicrobial chemotherapy, 73 ((2)): (452-455). [PMID:29149329]
42. Tony Velkov,Alejandra Gallardo-Godoy,James D Swarbrick,Mark A T Blaskovich,Alysha G Elliott,Meiling Han,Philip E Thompson,Kade D Roberts,Johnny X Huang,Bernd Becker,Mark S Butler,Lawrence H Lash,Sónia Troeira Henriques,Roger L Nation,Sivashangarie Sivanesan,Marc-Antoine Sani,Frances Separovic,Haydyn Mertens,Dieter Bulach,Torsten Seemann,Jeremy Owen,Jian Li,Matthew A Cooper. (2018-02-06) Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.. Cell chemical biology, 25 ((4)): (380-391). [PMID:29396290]
43. Xucheng Huang,Yingli Qiao,Yixuan Zhou,Zhi Ruan,Yingying Kong,Guoli Li,Xinyou Xie,Jun Zhang. (2018-07-24) Ureaplasma spp. lipid-associated membrane proteins induce human monocyte U937 cell cycle arrest through p53-independent p21 pathway.. International journal of medical microbiology : IJMM, 308 ((7)): (819-828). [PMID:30033344]
44. Tse-Kai Fu,Sim-Kun Ng,Yi-En Chen,Yuan-Chuan Lee,Fruzsina Demeter,Mihály Herczeg,Anikó Borbás,Cheng-Hsun Chiu,Chung-Yu Lan,Chyi-Liang Chen,Margaret Dah-Tsyr Chang. (2019-06-19) Rhamnose Binding Protein as an Anti-Bacterial Agent-Targeting Biofilm of Pseudomonas aeruginosa.. Marine drugs, 17 ((6)): [PMID:31207891]
45. Shunya Oka,Miku Okabe,Shuichi Tsubura,Masato Mikami,Akane Imai. (2019-06-20) Properties of fucoidans beneficial to oral healthcare.. Odontology, 108 ((1)): (34-42). [PMID:31214896]
46. Robert R Haines,Christopher D Scharer,Jenna L Lobby,Jeremy M Boss. (2019-09-08) LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development.. Journal of immunology (Baltimore, Md. : 1950), 203 ((7)): (1867-1881). [PMID:31492745]
47. Angelo Frei,Maite Amado,Matthew A Cooper,Mark A T Blaskovich. (2019-12-04) Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria.. Chemistry (Weinheim an der Bergstrasse, Germany), 26 ((13)): (2852-2858). [PMID:31788867]
48. Yanbin Ma,Yao Ding,Xianqiang Song,Xiaochuan Ma,Xun Li,Ning Zhang,Yunpeng Song,Yaping Sun,Yuqing Shen,Wenge Zhong,Liaoyuan A Hu,Yingli Ma,Mei-Yun Zhang. (2020-01-31) Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.. Science advances, 6 ((3)): (eaax7379-eaax7379). [PMID:31998837]
49. Alexandre Prehn Zavascki,Luciano Zubaran Goldani,Jian Li,Roger L Nation. (2007-09-20) Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review.. The Journal of antimicrobial chemotherapy, 60 ((6)): (1206-1215). [PMID:17878146]
50. Pragya Srivastava,Rajneesh Jha,Sylvette Bas,Sudha Salhan,Aruna Mittal. (2008-05-21) In infertile women, cells from Chlamydia trachomatis infected sites release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat-shock-protein stimulation than fertile women.. Reproductive biology and endocrinology : RB&E, 6 (20-20). [PMID:18489796]
51. Crystal Y Chen,Dan Huang,Richard C Wang,Ling Shen,Gucheng Zeng,Shuyun Yao,Yun Shen,Lisa Halliday,Jeff Fortman,Milton McAllister,Jim Estep,Robert Hunt,Daphne Vasconcelos,George Du,Steven A Porcelli,Michelle H Larsen,William R Jacobs,Barton F Haynes,Norman L Letvin,Zheng W Chen. (2009-04-22) A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.. PLoS pathogens, 5 ((4)): (e1000392-e1000392). [PMID:19381260]
52. Aoi Teruya,Kodai Kawamura,Kazuya Ichikado,Shinji Sato,Yuko Yasuda,Masakazu Yoshioka. (2013-12-04) Successful polymyxin B hemoperfusion treatment associated with serial reduction of serum anti-CADM-140/MDA5 antibody levels in rapidly progressive interstitial lung disease with amyopathic dermatomyositis.. Chest, 144 ((6)): (1934-1936). [PMID:24297126]
53. J E Aedo,A E Reyes,R Avendaño-Herrera,A Molina,J A Valdés. (2015-09-06) Bacterial lipopolysaccharide induces rainbow trout myotube atrophy via Akt/FoxO1/Atrogin-1 signaling pathway.. Acta biochimica et biophysica Sinica, 47 ((11)): (932-937). [PMID:26341977]
54. Ming Chen,Jiaxing Liu,Wenqi Yang,Wenhua Ling. (2017-11-22) Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling.. Autophagy, 13 ((11)): (1813-1827). [PMID:29160747]
55. Mei-Ling Han,Tony Velkov,Yan Zhu,Kade D Roberts,Anton P Le Brun,Seong Hoong Chow,Alina D Gutu,Samuel M Moskowitz,Hsin-Hui Shen,Jian Li. (2017-11-29) Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.. ACS chemical biology, 13 ((1)): (121-130). [PMID:29182311]
56. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652]
57. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
58. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
59. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
60. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
61. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
62. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
63. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.