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P421517-1ml

1ml

Available within 4-8 weeks(?)

$69.90

Basic Description

Synonyms	1405-20-5 \| Aerosporin \| MFCD00131991 \| PMB \| SR-05000002074 \| sufuric acid \| KS-1428 \| NCGC00094763-01 \| SPECTRUM1500492 \| HMS502E14 \| HFMDLUQUEXNBOP-UHFFFAOYSA-N \| HMS1920J04 \| HMS2092A07 \| Pharmakon1600-01500492 \| BCP12700 \| CCG-39724 \| NSC757278 \| s1395 \| AKOS015895662 \| NCGC00094763-02 \| N
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae. Mode of Action: Polymyxin B Sulfate bind
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Chemical structure: peptide Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Polymyxin B sulfate salt has been used: • in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin • in the analysis of the isolates • in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)

Names and Identifiers

IUPAC Name	N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
INCHI	InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
InChi Key	HFMDLUQUEXNBOP-UHFFFAOYSA-N
Canonical SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
Isomeric SMILES	CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
RTECS	TR1150000
PubChem CID	5702105
Molecular Weight	1301.6

Certificates

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Chemical and Physical Properties

Sensitivity	Light & heat sensitive.
Specific Rotation[α]	-80 ° (C=2, H2O)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
RTECS	TR1150000
Merck Index	7573

FAQs and Articles

FAQ

Antimicrobial Peptides: A Promising Field in Antibiotic Research

Categories: Technical articles

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Antibiotics Natural products Immunology Antimicrobial ligands Peptides WHO Essential Medicine ligands Human endogenous peptides Antimicrobial peptides RAMPs Biology of Cells

Citations of This Product

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652]
2. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
3. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
4. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
5. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
6. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
7. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
8. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]

References

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652]
2. Yu Yong-Lin, Wu Jun-Jie, Lin Chuan-Chuan, Qin Xian, Tay Franklin R., Miao Li, Tao Bai-Long, Jiao Yang. (2023) Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration. Military Medical Research, 10 (1): (1-23). [PMID:37143145]
3. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen. (2023) A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis. ACS Nano, 17 (9): (8551–8563). [PMID:37129445]
4. Leilei Sun, Yao Huang, Chenhui Ji, Craig A. Grimes, Qingyun Cai. (2023) NIR-II multiplexed fluorescence imaging of bacteria based on excitation-selective lanthanide-doped core-shell nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, 384 (133669). [PMID:]
5. Hebin Liang, Jiayu Zhang, Jiahui Hu, Xiaoyan Li, Bing Li. (2023) Fluoroquinolone Residues in the Environment Rapidly Induce Heritable Fluoroquinolone Resistance in Escherichia coli. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 57 (12): (4784–4795). [PMID:36917150]
6. Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu. (2022) Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (50): (15903–15916). [PMID:36511360]
7. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723]
8. Rouying Cai, Chenfang Miao, Liang Zhang, Yi Zhou, Yuebin Liu, Chen Zheng, Wendi Han, Zhengjun Huang, Xin Zhou, Shaohuang Weng. (2022) Determination and the pharmacokinetic study of tigecycline by fluorescence strategy with F, N codoping carbon dots as probe. SENSORS AND ACTUATORS B-CHEMICAL, 361 (131721). [PMID:]

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Polymyxin B sulfate - 10mM in Water, high purity , CAS No.1405-20-5