Pomalidomide-PEG2-azide - 95%, high purity , CAS No.2267306-14-7

Item Number

P486924

Grouped product items
SKU	Size	Availability	Price	Qty
P486924-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$599.90
P486924-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90

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Basic Description

Specifications & Purity	95%
Legal Information	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Description Protein degrader builiding block Pomalidomide-PEG2-azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Names and Identifiers

IUPAC Name	2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
INCHI	InChI=1S/C19H20N6O7/c20-24-21-6-7-31-8-9-32-10-15(27)22-12-3-1-2-11-16(12)19(30)25(18(11)29)13-4-5-14(26)23-17(13)28/h1-3,13H,4-10H2,(H,22,27)(H,23,26,28)
InChi Key	QMQAWNMGKYQDLT-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)COCCOCCN=[N+]=[N-]
PubChem CID	155292127
Molecular Weight	444.40

Certificates

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4 results found

Lot Number	Certificate Type	Date	Item
B2427303	Certificate of Analysis	Jan 20, 2024	P486924
B2427304	Certificate of Analysis	Jan 20, 2024	P486924
B2427305	Certificate of Analysis	Jan 20, 2024	P486924
B2427315	Certificate of Analysis	Jan 20, 2024	P486924

Sensitivity

Light sensitive

Flash Point(°F)

Not applicable

Flash Point(°C)

Not applicable

Melt Point(°C)

188℃

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Basic Description