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Ponalrestat - ≥95%, high purity , CAS No.72702-95-5

≥95%

CAS#: 72702-95-5
Formula: C₁₇H₁₂BrFN₂O₃
Molecular Weight: 391.2
PubChem CID: 5278

Item Number

S343067

Grouped product items
SKU	Size	Availability	Price
S343067-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
S343067-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$99.90
S343067-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$159.90
S343067-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$259.90

an aldose reductase inhibitor

View related series

Aldose Reductase Metabolic Enzyme/Protease

Basic Description

Synonyms	PONALRESTAT\|statil\|72702-95-5\|2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid\|ICI-128436\|ICI 128,436\|CHEMBL7679\|2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxophthalazin-1-yl]acetic acid\|2CV0A5G64E\|DTXSID1045665\|3-(4-Bromo-2-fluorob
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 3 Activities

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1A1 Tchem Alcohol dehydrogenase [NADP(+)] 0 Activities

Discover Target: AKR1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxophthalazin-1-yl]acetic acid
INCHI	InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChi Key	LKBFFDOJUKLQNY-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=NN(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O)O
Isomeric SMILES	C1=CC=C2C(=C1)C(=NN(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O)O
PubChem CID	5278
Molecular Weight	391.2

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
C2429254	Certificate of Analysis	Feb 20, 2024	S343067
C2429255	Certificate of Analysis	Feb 20, 2024	S343067
C2429261	Certificate of Analysis	Feb 20, 2024	S343067
C2429264	Certificate of Analysis	Feb 20, 2024	S343067
C2429269	Certificate of Analysis	Feb 20, 2024	S343067
C2429270	Certificate of Analysis	Feb 20, 2024	S343067
C2429271	Certificate of Analysis	Feb 20, 2024	S343067
C2429276	Certificate of Analysis	Feb 20, 2024	S343067

Solubility

Soluble in DMSO (100 mM), and ethanol (25 mM).

Sensitivity

Moisture sensitive

Refractive Index

n20D1.66 (Predicted)

Boil Point(°C)

576.33° C at 760 mmHg (Predicted)

Melt Point(°C)

224.29° C (Predicted)

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