Ponatinib hydrochloride - 99%, high purity , Bcr/Abl fusion protein inhibitor, CAS No.1114544-31-8, Bcr/Abl fusion protein inhibitor

Item Number

P649469

Grouped product items
SKU	Size	Availability	Price
P649469-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$22.90
P649469-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$36.90
P649469-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$67.90
P649469-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$106.90
P649469-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$162.90
P649469-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$269.90
P649469-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$410.90

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Basic Description

Synonyms	Ponatinib hydrochloride\|1114544-31-8\|Ponatinib HCl\|Iclusig\|AP 24534 hydrochloride\|AP24534 HCL\|Ponatinib Mono-hydrochloride\|UNII-96R6PU3D8J\|96R6PU3D8J\|Ponatinib hydrochloride [USAN]\|AP-24534 HCl\|Ponatinib (hydrochloride)\|AP-24534 hydrochloride\|CHEBI:191940
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Bcr/Abl fusion protein inhibitor
Product Description	Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC 50 s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl , PDGFRα , VEGFR2 , FGFR1 , and Src , respectively Form:Solid IC50& Target:LYN 0.24 nM (IC 50 ) Abl 0.37 nM (IC 50 ) PDGFRα 1.1 nM (IC 50 ) VEGFR2 1.5 nM (IC 50 ) FGFR1 2.2 nM (IC 50 ) Src 5.4 nM (IC 50 )

Names and Identifiers

IUPAC Name	3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
INCHI	InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H
InChi Key	BWTNNZPNKQIADY-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl
Isomeric SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl
Alternate CAS	1114544-31-8
PubChem CID	46908927
MeSH Entry Terms	3-(2-(imidazo(1,2-b)pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-y-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide;AP 24534;AP-24534;AP24534;Iclusig;ponatinib;ponatinib hydrochloride
Molecular Weight	569.02

Solubility

DMSO : 25 mg/mL (43.94 mM; ultrasonic and warming and heat to 60°C)

Sensitivity

Moisture sensitive

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Basic Description