Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis
Product Properties
ALogP
4.1
Associated Targets
CD69Tchem Early activation antigen CD69 0 Activities
1.Park JK, Byun JY, Park JA, Kim YY, Lee YJ, Oh JI, Jang SY, Kim YH, Song YW, Son J et al.. (2015) HM71224, a novel Bruton's tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis.. Arthritis Res Ther, 18 (3):(91). [PMID:27090981]
2.Kim YY, Park KT, Jang SY, Lee KH, Byun JY, Suh KH, Lee YM, Kim YH, Hwang KW. (2017) HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus.. Arthritis Res Ther, 19 (1):(211). [PMID:28950886]
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