Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

Praeruptorin B - 99%, high purity , CAS No.73069-28-0

  • ≥99%
Item Number
P651602
Grouped product items
SKUSizeAvailabilityPrice Qty
P651602-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$150.90
P651602-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$240.90
P651602-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$480.90

Phenylpropanoids Coumarins

Basic Description

SynonymsAKOS037515272 | CCG-268959 | Q-100803 | (-)-Praeruptorin B | CCG-268960 | E80827 | HY-N0082 | (9S,10S)-8,8-Dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromene-9,10-diyl (2Z,2'Z)-bis(2-methylbut-2-enoate) | Praeruptorin D | Praeruptorin B | CS-0007122
Specifications & Purity≥99%
Biochemical and Physiological MechanismsPraeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs) .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs) .

In Vitro

Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:SREBP

Names and Identifiers

IUPAC Name [(9S,10S)-8,8-dimethyl-9-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (Z)-2-methylbut-2-enoate
INCHI InChI=1S/C24H26O7/c1-7-13(3)22(26)29-20-18-16(11-9-15-10-12-17(25)28-19(15)18)31-24(5,6)21(20)30-23(27)14(4)8-2/h7-12,20-21H,1-6H3/b13-7-,14-8-/t20-,21-/m0/s1
InChi Key PNTWXEIQXBRCPS-UWOGZXHISA-N
Canonical SMILES CC=C(C)C(=O)OC1C(C(OC2=C1C3=C(C=C2)C=CC(=O)O3)(C)C)OC(=O)C(=CC)C
Isomeric SMILES C/C=C(/C)\C(=O)O[C@@H]1[C@@H](C(OC2=C1C3=C(C=C2)C=CC(=O)O3)(C)C)OC(=O)/C(=C\C)/C
Alternate CAS 73069-28-0,73069-26-8
PubChem CID 25717254
MeSH Entry Terms anomalin;anomalin, (9alpha(E),10alpha(E));anomalin, (9S-(9alpha(Z),10alpha(Z)))-isomer;anomalin, (Z,Z)-isomer;praeruptorin B
Molecular Weight 426.46

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilityDMSO : 25 mg/mL (58.62 mM; ultrasonic and warming and heat to 60°C)

Related Documents

Solution Calculators