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PRE-084 hydrochloride - ≥99%(HPLC), high purity , CAS No.138847-85-5, Agonist of sigma non-opioid intracellular receptor 1

Moligand™
≥99%(HPLC)

CAS#: 138847-85-5
Formula: C₁₉H₂₇NO₃.HCl
Molecular Weight: 353.89
PubChem CID: 126402

Item Number

P288761

Grouped product items
SKU	Size	Availability	Price	Qty
P288761-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$153.90
P288761-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$636.90

Highly selective σ1agonist

View related series

sigma non-opioid intracellular receptor 1 Agonist

Basic Description

Synonyms	Pre-084\|138847-85-5\|Pre 084\|2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate\|2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate\|2-Morpholinoethyl 1-Phenylcyclohexanecarboxylate\|Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl este
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	High affinity, selectiveσ1agonist (Kivalues are 2.2 and 13091 nM forσ1andσ2receptors respectively). Selective over PCP receptors (IC50> 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effectsin vivo. Also exhibits prote
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of sigma non-opioid intracellular receptor 1

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

Discover Target: SLC6A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TMEM97 Tchem Sigma intracellular receptor 2 0 Activities

Discover Target: TMEM97

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 2 Activities

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRCP Tchem Lysosomal Pro-X carboxypeptidase 0 Activities

Discover Target: PRCP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PKM Tchem Pyruvate kinase PKM 0 Activities

Discover Target: PKM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ARSA Tbio Arylsulfatase A 0 Activities

Discover Target: ARSA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
INCHI	InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2
InChi Key	RQHKZUBCUZVZEF-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3
Isomeric SMILES	C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3
PubChem CID	126402
Molecular Weight	353.89

PubChem CID

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CAS Registry No.

ChEMBL Ligand

RCSB PDB Ligand

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