One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.End
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR. An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.
1.Vallée M, Mayo W, Le Moal M. (2001) Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.. Brain Res Brain Res Rev, 37 (1-3):(301-12). [PMID:11744095]
2.Reddy DS. (2010) Neurosteroids: endogenous role in the human brain and therapeutic potentials.. Prog Brain Res, 186 (3):(113-37). [PMID:21094889]
3.Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen TB, Lieberman JA, Strauss JL, Kilts JD. (2011) Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.. Neuroscience, 191 (3):(78-90). [PMID:21756978]
4.Harteneck C. (2013) Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.. Molecules, 18 (10):(12012-28). [PMID:24084011]
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