Propargyl-PEG4-alcohol is a PEG derivative containing a hydroxyl group and a propargyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.
1.Dahua Li, Yuzhi Xing, Lan Ding, Chengfeng Wu, Guangliang Hou, Bo Song. (2018) Tuning the emission of a water-soluble 3-hydroxyflavone derivative by host–guest complexation. Soft Matter, 14 (21):(4231-4237). [PMID:29624193][10.1039/C8SM00349A]
References
1.Dahua Li, Yuzhi Xing, Lan Ding, Chengfeng Wu, Guangliang Hou, Bo Song. (2018) Tuning the emission of a water-soluble 3-hydroxyflavone derivative by host–guest complexation. Soft Matter, 14 (21):(4231-4237). [PMID:29624193][10.1039/C8SM00349A]
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