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Prostaglandin E₃ - A solution in methyl acetate, high purity , CAS No.802-31-3
a metabolite found in ocular tissue
Basic Description Synonyms prostaglandin E3 | AKOS027381955 | PGE3 | (-)-prostaglandin E3 | PGE1, delta(17)- | C06439 | 7-[3-hydroxy-2-(3-hydroxy-1,5-octadienyl)-5-oxocyclopentyl]-5-Heptenoic acid | SCHEMBL3366416 | (5Z,13E,15S,17Z)-11alpha,15-dihydroxy-9-oxoprosta-5,13,17-trien-1- Specifications & Purity ≥98%, 500 ug/mL in methyl acetate Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description
Prostaglandin E3 is formed via the COX metabolism of eicosapentaenoic acid, where in human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 μg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopentyl]hept-5-enoic acid INCHI InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 InChi Key CBOMORHDRONZRN-QLOYDKTKSA-N Canonical SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)[C@H](O)C1 Isomeric SMILES CC/C=C\C[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O PubChem CID 5280937 Molecular Weight 350.45 Beilstein 2899956
Chemical and Physical Properties Solubility Soluble in ethanol (~100 mg/ml), DMSO (~100 mg/ml), DMF (~100 mg/ml), PBS (pH7.2) (~5 mg/ml), and water (>5 mg/ml at 25° C). Refractive Index n20D1.58 (Predicted) Boil Point(°C) 57° C Melt Point(°C) -98.05° C
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