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PROTAC AR-V7 degrader-1 - 10mM in DMSO, high purity , CAS No.2767440-24-2(DMSO)

PROTAC AR-V7 degrader-1 - 10mM in DMSO, high purity , CAS No.2767440-24-2(DMSO)

Item Number

P654659

Grouped product items
SKU	Size	Availability	Price	Qty
P654659-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$825.90

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Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC 50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC 50 of 0.88 µM IC50& Target:VHL

Canonical SMILES	O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
Molecular Weight	789.02

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