| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P654659-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $825.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Biochemical and Physiological Mechanisms | PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orallyxa0bioavailable and selective AR-V7 degrader with the DC 50 of 0.32xa0µM by recruiting VHL E3xa0ligasexa0to Androgen receptorxa0(AR) DNA bindingxa0domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibit |
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC 50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC 50 of 0.88 µM IC50& Target:VHL |
| Canonical SMILES | O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O |
|---|---|
| Molecular Weight | 789.02 |
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