PROTAC CDK9 Degrader-1 - 98%, high purity , CAS No.2118356-96-8

Item Number

P650019

Grouped product items
SKU	Size	Availability	Price	Qty
P650019-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$640.90	+-
P650019-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90	+-

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	PROTAC CDK9 Degrader-1 is a PROTAC connected by ligands for Cereblon and CDK as a selective CDK9 degrader.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	PROTAC CDK9 Degrader-1 is a PROTAC connected by ligands for Cereblon and CDK as a selective CDK9 degrader. In Vitro PROTAC CDK9 Degrader-1 (Compound 3; 2.5-20 μM; 6 hours) degrades CDK9 in a dose dependent manner in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HCT116 cells Concentration: 2.5, 5, 10, and 20μM Incubation Time: 6 hours Result: Degraded CDK9 in a dose dependent manner. Form:Solid IC50& Target:CDK9

Names and Identifiers

IUPAC Name	N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-[4-[5-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxypentoxy]phenyl]acetamide
INCHI	InChI=1S/C33H35N5O7/c39-28-15-14-25(31(41)35-28)38-32(42)23-8-5-9-26(30(23)33(38)43)45-17-3-1-2-16-44-22-12-10-20(11-13-22)18-29(40)34-27-19-24(36-37-27)21-6-4-7-21/h5,8-13,19,21,25H,1-4,6-7,14-18H2,(H,35,39,41)(H2,34,36,37,40)
InChi Key	WCEHIDWONYOKOJ-UHFFFAOYSA-N
Canonical SMILES	C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC=C(C=C3)OCCCCCOC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O
Isomeric SMILES	C1CC(C1)C2=CC(=NN2)NC(=O)CC3=CC=C(C=C3)OCCCCCOC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O
PubChem CID	132472236
Molecular Weight	613.7

Chemical and Physical Properties

Solubility	DMSO : ≥ 104 mg/mL (169.47 mM)
Molecular Weight	613.700 g/mol
XLogP3	3.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	13
Exact Mass	613.254 Da
Monoisotopic Mass	613.254 Da
Topological Polar Surface Area	160.000 Å²
Heavy Atom Count	45
Formal Charge	0
Complexity	1110.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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Basic Description