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Protein kinase inhibitor H-7 - 98%, high purity , CAS No.84477-87-2

  • ≥98%
Item Number
H330535
Grouped product items
SKUSizeAvailabilityPrice Qty
H330535-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
H330535-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
H330535-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
H330535-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$279.90

an inhibitor of PKA and PKC

View related series
PKC TGF-beta/Smad

Basic Description

SynonymsHMS2231B22 | 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline | MLS000069615 | SCHEMBL190590 | cid_3542 | CS-0142529 | NCGC00015487-09 | BRD6846 | BRD-6846 | NCGC00015487-12 | 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE | H-7 inhibitor | DB07996 | HY-1319
Specifications & Purity≥98%
Storage TempStore at 2-8°C,Protected from light
Shipped InWet ice
Product Description

H-7 is an inhibitor of the cyclic nucleotide dependent protein kinases PKA and PKC.

Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC.


Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMN1 Tchem Survival motor neuron protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATXN2 Tbio Ataxin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTT Tchem Huntingtin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
INCHI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3
InChi Key BDVFVCGFMNCYPV-UHFFFAOYSA-N
Canonical SMILES CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Isomeric SMILES CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3
WGK Germany 3
RTECS TL9305000
PubChem CID 3542
Molecular Weight 291.37

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
B2426836Certificate of AnalysisJan 19, 2024 H330535
B2426837Certificate of AnalysisJan 19, 2024 H330535
B2426842Certificate of AnalysisJan 19, 2024 H330535
B2426845Certificate of AnalysisJan 19, 2024 H330535
B2426847Certificate of AnalysisJan 19, 2024 H330535
B2426848Certificate of AnalysisJan 19, 2024 H330535
B2426849Certificate of AnalysisJan 19, 2024 H330535
B2426850Certificate of AnalysisJan 19, 2024 H330535

Chemical and Physical Properties

SolubilitySoluble in Ethanol: 20 mg/mL and 1 M HCl: 5 mg/mL
Sensitivitylight sensitive
Boil Point(°C)~495.3° C at 760 mmHg (Predicted)
Melt Point(°C)114° C

Safety and Hazards(GHS)

WGK Germany 3
RTECS TL9305000
RIDADR NONHforallmodesoftransport

Related Documents

Solution Calculators