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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P347552-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $132.90 | |
P347552-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $555.90 |
a high affinity histamine H3 receptor ligand
Specifications & Purity | Moligand™, ≥98% |
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Storage Temp | Room temperature,Desiccated |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of H 3 receptor;Antagonist of H 3 receptor |
Product Description | Proxyfan oxalate is a high affinity histamine H|3|receptor ligand (pKi = 8.62) that acts as a protean (shape changing) agonist at recombinant and native receptors. This compound's functional activity ranges from full agonist to inverse agonist depending on the system used. Proxyfan oxalate displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [3H]-arachidonic acid release. |
pKa | pKₐ: 7.4 (Predicted) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Canonical SMILES | C1=CC=C(C=C1)COCCCC2=CN=CN2.C(=C\\\\C(=O)O)\\\\C(=O)O |
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Isomeric SMILES | C1=CC=C(C=C1)COCCCC2=CN=CN2.C(=C\C(=O)O)\C(=O)O |
PubChem CID | 44303497 |
Molecular Weight | 306.32 |
PubChem CID | 6421522 |
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Wikipedia | Proxyfan |
ChEMBL Ligand | CHEMBL19173 |
BindingDB Ligand | 22915 |
CAS Registry No. | 177708-09-7 |
GPCRdb Ligand | proxyfan |
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Solubility | Soluble in water (100 mM), and DMSO (100 mM). |
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