PTP Inhibitor IV - ≥95%, high purity , CAS No.329317-98-8

Item Number

P334412

Grouped product items
SKU	Size	Availability	Price
P334412-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
P334412-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$127.90
P334412-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$219.90
P334412-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$349.90
P334412-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$559.90
P334412-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,199.90

a potent, reversible, competitive, & active-site directed inhibitor of PTP

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Basic Description

Synonyms	PTP Inhibitor IV\|329317-98-8\|Protein Tyrosine Phosphatase Inhibitor IV\|1,1,1-trifluoro-N-[4-[2-[4-[2-[4-(trifluoromethylsulfonylamino)phenyl]propan-2-yl]phenyl]propan-2-yl]phenyl]methanesulfonamide\|N,N'-((1,4-Phenylenebis(propane-2,2-diyl))bis(4,1-phenyle
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM,
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	PTP Inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. PTP Inhibitor IV is an inhibitor of PTP β, PTP ε, PTP μ, PTP σ, PTP-MEG, PTP1B and SH-PTP2.

Names and Identifiers

IUPAC Name	1,1,1-trifluoro-N-[4-[2-[4-[2-[4-(trifluoromethylsulfonylamino)phenyl]propan-2-yl]phenyl]propan-2-yl]phenyl]methanesulfonamide
INCHI	InChI=1S/C26H26F6N2O4S2/c1-23(2,19-9-13-21(14-10-19)33-39(35,36)25(27,28)29)17-5-7-18(8-6-17)24(3,4)20-11-15-22(16-12-20)34-40(37,38)26(30,31)32/h5-16,33-34H,1-4H3
InChi Key	JWNAVYMNAQDLHX-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)NS(=O)(=O)C(F)(F)F
Isomeric SMILES	CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)NS(=O)(=O)C(F)(F)F
PubChem CID	6420094
Molecular Weight	608.61

Solubility

Soluble in DMSO (10 mg/ml), and ACN.

Refractive Index

n20D1.56 (Predicted)

Boil Point(°C)

~578.0° C at 760 mmHg (Predicted)

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Basic Description