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Puerarin - analytical standard,≥98%, high purity , CAS No.3681-99-0, Activator of TRPV4

  • analytical standard
  • Moligand™
  • ≥98%
Item Number
P111269
Grouped product items
SKUSizeAvailabilityPrice Qty
P111269-20mg
20mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$31.90
P111269-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$138.90
P111269-500mg
500mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$581.90

Plant derived isoflavone

View related series
TRPV4 Activator

Basic Description

SynonymsPuerarin|3681-99-0|Kakonein|Daidzein-8-C-glucoside|7-hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one|Puerarin 80 mm|CHEBI:8633|Daidzein 8-c-glucoside|NPI 031G|7-hydroxy-3-(4-hydr
Specifications & PurityMoligand™, analytical standard, ≥98%
Biochemical and Physiological MechanismsPlant derived isoflavone. Various pharmacological functions including antioxidant, anti-inflammatory and antiapoptotic. Enhances superoxide dismutase activity. Neuroprotective and anti-ischaemic effects in vivo. Orally active
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Gradeanalytical standard, Moligand™
Action TypeACTIVATOR
Mechanism of actionActivator of TRPV4
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FABP4 Tchem Fatty acid-binding protein, adipocyte 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MGLL Tchem Monoglyceride lipase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA7 Tclin Carbonic anhydrase 7 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
INCHI InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1
InChi Key HKEAFJYKMMKDOR-VPRICQMDSA-N
Canonical SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
Isomeric SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
WGK Germany 3
RTECS UO5216000
Alternate CAS 3681-99-0
PubChem CID 5281807
MeSH Entry Terms 7,4'-dihydroxyisoflavone-8beta-glucopyranoside;kakonein;puerarin
Molecular Weight 416.38
Beilstein 64198
Reaxy-Rn 64198

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

7 results found

Lot NumberCertificate TypeDateItem
H2231769Certificate of AnalysisJun 19, 2024 P111269
D2423014Certificate of AnalysisApr 30, 2024 P111269
D2423031Certificate of AnalysisApr 30, 2024 P111269
G2314128Certificate of AnalysisAug 17, 2022 P111269
H2231612Certificate of AnalysisAug 17, 2022 P111269
H2231764Certificate of AnalysisAug 17, 2022 P111269
L2308013Certificate of AnalysisAug 17, 2022 P111269

Chemical and Physical Properties

Sensitivityair & heat & Moisture sensitive
Melt Point(°C)187-189°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS UO5216000
Reaxy-Rn 64198

Related Documents

References

1. Huang SR et al..  (2020)  Puerarin alleviates the progression of non-small cell lung cancer by regulating the miR-342/CCND1 axis..  Neoplasma,  67  (6): (1244-1255).  [PMID:32749850]
2. Wen S et al..  (2021)  Puerarin Attenuates Cadmium-Induced Neuronal Injury via Stimulating Cadmium Excretion, Inhibiting Oxidative Stress and Apoptosis..  Biomolecules,  11  (7):   [PMID:34356602]

Solution Calculators