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Basic Description
| Synonyms | PURPURIN|81-54-9|Verantin|1,2,4-Trihydroxyanthraquinone|Hydroxylizaric acid|Purpurine|1,2,4-trihydroxyanthracene-9,10-dione|Smoke Brown G|1,2,4-Trihydroxy-9,10-anthracenedione|1,2,4-Trihydroxy-9,10-anthraquinone|1,2,4-Trihydroxyanthrachinon|C.I. 58205|Ant |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Purpurin is a xanthine oxidase inhibitor that reduces the formation of azoxymethane-induced aberrant crypt foci in rat colon studies. |
Associated Targets
CYP1B1 Tchem Cytochrome P450 1B1 1 Activities
CYP3A4 Tclin Cytochrome P450 3A4 0 Activities
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ERG Tbio Transcriptional regulator ERG 0 Activities
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HSPD1 Tbio 60 kDa heat shock protein, mitochondrial 0 Activities
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CBX1 Tbio Chromobox protein homolog 1 0 Activities
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POLH Tchem DNA polymerase eta 0 Activities
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TUBB1 Tclin Tubulin beta-1 chain 0 Activities
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RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 0 Activities
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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities
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VDR Tclin Vitamin D3 receptor 0 Activities
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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities
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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities
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FEN1 Tchem Flap endonuclease 1 0 Activities
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KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities
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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities
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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities
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WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities
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TST Tchem Thiosulfate sulfurtransferase 0 Activities
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TTR Tclin Transthyretin 0 Activities
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POLK Tbio DNA polymerase kappa 0 Activities
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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities
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POLI Tchem DNA polymerase iota 0 Activities
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PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities
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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities
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RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities
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MMP14 Tchem Matrix metalloproteinase-14 0 Activities
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ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 0 Activities
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L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 0 Activities
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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities
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BRCA1 Tchem Breast cancer type 1 susceptibility protein 0 Activities
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CYP1A1 Tchem Cytochrome P450 1A1 0 Activities
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ATXN2 Tbio Ataxin-2 0 Activities
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities
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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities
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MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities
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MAOA Tclin Amine oxidase [flavin-containing] A 1 Activities
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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities
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TARDBP Tchem TAR DNA-binding protein 43 0 Activities
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MAPT Tclin Microtubule-associated protein tau 0 Activities
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IMPA1 Tclin Inositol monophosphatase 1 0 Activities
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GLS Tchem Glutaminase kidney isoform, mitochondrial 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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KDM4A Tchem Lysine-specific demethylase 4A 0 Activities
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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities
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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities
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Names and Identifiers
| IUPAC Name | 1,2,4-trihydroxyanthracene-9,10-dione |
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| INCHI | InChI=1S/C14H8O5/c15-8-5-9(16)14(19)11-10(8)12(17)6-3-1-2-4-7(6)13(11)18/h1-5,15-16,19H |
| InChi Key | BBNQQADTFFCFGB-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3O)O)O |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3O)O)O |
| RTECS | CB8200000 |
| PubChem CID | 6683 |
| Molecular Weight | 256.21 |
| Beilstein | 8509 |
| Reaxy-Rn | 1887127 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Melt Point(°C) | 253-256 °C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| RTECS | CB8200000 |
| Reaxy-Rn | 1887127 |
| Merck Index | 7945 |