| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| P355515-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $813.90 |
an analog of Sildenafil and a potential PDE5 inhibitor
| Synonyms | 5-(2-Ethoxy-5-((4-methyl-1-piperazinyl)sulfonyl)phenyl)-1,6-dihydro-3-propyl-7H-pyrazolo(4,3-d)pyrimidin-7-one | Q27285990 | UNII-P1243M9SVH | 5-(2-Ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-3-propyl-1,6-dihydro-7H-pyrazolo(4,3-d)pyrimidin-7-one | C |
|---|---|
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Pyrazole N-Demethyl Sildenafil is an analog of Sildenafil . Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-3-propyl-2,6-dihydropyrazolo[4,3-d]pyrimidin-7-one |
|---|---|
| INCHI | InChI=1S/C21H28N6O4S/c1-4-6-16-18-19(25-24-16)21(28)23-20(22-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-26(3)10-12-27/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,25)(H,22,23,28) |
| InChi Key | ZLJVUHMTFSCAGQ-UHFFFAOYSA-N |
| Canonical SMILES | CCCC1=C2C(=NN1)C(=O)NC(=N2)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC |
| Isomeric SMILES | CCCC1=C2C(=NN1)C(=O)NC(=N2)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC |
| PubChem CID | 135543792 |
| Molecular Weight | 460.55 |
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| Solubility | Soluble in DMF, DMSO and Methanol |
|---|---|
| Melt Point(°C) | 232-234°C (lit.) |
