Q-dextran - 150 kDa, high purity , CAS No.Q292467

Item Number

Q292467

• Synonyms: Q -dextran 150;O-Trimethylammonium-glycidyl-dextran
• Specifications & Purity: 150 kDa
• Storage Temp: Store at 2-8°C,Argon charged
• Shipped In: Wet ice

Product Description

Q-dextran is a polycationic derivative of dextran. These derivatives are distinct from DEAE-dextrans in that they only contain quaternary amine groups. Unlike DEAE-dextrans, Q-dextrans will be charged over a wide range of pH (pH 4-10). Q-dextrans will also have a much stronger net charge than corresponding DEAE-dextrans. All batches are checked for molecular weight, degree of substitution and loss on drying. Aladdin produce Q-dextran from 4 kDa to 150 kDa. Q-dextrans are supplied as a white powder.

Structure

Q-dextrans are synthesised by reacting dextran fractions with 2,3-epoxypropyltrimethylammonium chloride. The nitrogen content is approximately 2% which corresponds to one quaternary ammonium group for every four glucose units.

Application

Polycationic products exhibit a wide variety of effects in cellular systems and are of interest as adjuvants in vaccines. Q-dextran has a much stronger net charge than corresponding DEAE-dextrans and will thus give enhanced responses in systems where this effect is important.