| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Q655526-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $638.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC 50 =7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. In Vitro SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC 50 of 5 μM in HeLa S100 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | C1C(N(C(=O)CN(C1=O)CCC2=C(C=C(C=C2)Cl)Cl)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)N(CCC5=C(C=C(C=C5)Cl)Cl)CC(=O)N |
|---|---|
| Molecular Weight | 768.56 |
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