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Quinaprilat , CAS No.82768-85-2, Inhibitor of Angiotensin-converting enzyme

Moligand™

CAS#: 82768-85-2
Formula: C₂₃H₂₆N₂O₅
Molecular Weight: 410.46
PubChem CID: 107994

Item Number

Q331175

Grouped product items
SKU	Size	Availability	Price
Q331175-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$332.90
Q331175-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$427.90
Q331175-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,285.90

a metabolite of Quinapril that acts as an ACE inhibitor

View related series

Angiotensin-converting enzyme Inhibitor

Basic Description

Synonyms	Quinaprilat\|82768-85-2\|CI-928\|CI 928\|quinaprilate\|quinaprilatum\|Quinapril diacid\|CI928\|UNII-34SSX5LDE5\|34SSX5LDE5\|NSC-759825\|BRN 5653070\|CL-928\|CHEBI:140296\|DTXSID40868904\|NSC 759825\|(3s)-2-{n-[(1s)-1-carboxy-3-phenylpropyl]-l-alanyl}-1,2,3,4-tetrahydrois
Specifications & Purity	Moligand™
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Angiotensin-converting enzyme
Product Description	Quinaprilat is the active metabolite of Quinapril and a ACE (angiotensin converting enzyme) inhibitor. This compound prevents the catalyzed conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, and by preventing its formation, vasodilation occurs along with increased capillary blood volume.

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 0 Activities

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ESR1 Tclin Estrogen receptor 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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HRH3 Tclin Histamine H3 receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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SLC6A2 Tclin Sodium-dependent noradrenaline transporter 0 Activities

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SLC6A3 Tclin Sodium-dependent dopamine transporter 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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PGR Tclin Progesterone receptor 0 Activities

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PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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PDE4A Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4A 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 0 Activities

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ACE Tclin Angiotensin-converting enzyme 4 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 0 Activities

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TBXA2R Tclin Thromboxane A2 receptor 0 Activities

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F2 Tclin Prothrombin 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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Names and Identifiers

IUPAC Name	(3S)-2-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
INCHI	InChI=1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1
InChi Key	FLSLEGPOVLMJMN-YSSFQJQWSA-N
Canonical SMILES	CC(C(=O)N1CC2=CC=CC=C2CC1C(=O)O)NC(CCC3=CC=CC=C3)C(=O)O
Isomeric SMILES	C[C@@H](C(=O)N1CC2=CC=CC=C2C[C@H]1C(=O)O)N[C@@H](CCC3=CC=CC=C3)C(=O)O
PubChem CID	107994
Molecular Weight	410.46

PubChem CID

Wikipedia

ChEMBL Ligand

CAS Registry No.

Reactome Reaction

R-HSA-9614933, R-HSA-9619034

Reactome Drug

R-ALL-9614942, R-ALL-9619017

Solubility

Soluble in methanol.

Refractive Index

n20D1.61 (Predicted)

Specific Rotation[α]

α20/D +19.5°±3.5°, c = 1 in methanol

Boil Point(°C)

~674.5° C at 760 mmHg (Predicted)

Melt Point(°C)

144-146° C

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