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quinazolin-4(3H) derivative 36 , CAS No.2314467-59-7, Activator of TRPV4

  • Moligand™
Item Number
Q613050
Grouped product items
SKUSizeAvailabilityPrice Qty
Q613050-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
Q613050-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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TRPV4 Activator

Basic Description

Synonymscompound 36;TRPV4 agonist 36
Specifications & PurityMoligand™
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of TRPV4

Associated Targets

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one
INCHI InChI=1S/C25H22F2N4O2/c1-29-13-15-30(16-14-29)25-28-23-21(3-2-4-22(23)27)24(32)31(25)18-7-11-20(12-8-18)33-19-9-5-17(26)6-10-19/h2-12H,13-16H2,1H3
InChi Key NUGPMKZYSBKNPU-UHFFFAOYSA-N
Canonical SMILES CN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
Isomeric SMILES CN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
PubChem CID 137628676

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Atobe M, Nagami T, Muramatsu S, Ohno T, Kitagawa M, Suzuki H, Ishiguro M, Watanabe A, Kawanishi M.  (2019)  Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis..  J Med Chem,  62  (3): (1468-1483).  [PMID:30629441]

Solution Calculators

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