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Quinine sulfate dihydrate - biological reagent grade，99.0%,BioReagent, suitable for fluorescence, high purity , CAS No.6119-70-6

  • BioReagent
  • for fluorescence analysis
  • ≥99%
Item Number
Q110176
Grouped product items
SKUSizeAvailabilityPrice Qty
Q110176-5g
5g
In stock
$9.90
Q110176-25g
25g
In stock
$38.90
Q110176-100g
100g
In stock
$136.90
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Bulk Order  SDS  DATASHEET

Potassium channel blocker.

Basic Description

Synonymsquinine sulfate|207671-44-1|QUININE SULFATE DIHYDRATE|Chininum sulphuricum|Quinamm|Quinine hemisulfate salt monohydrate|6119-70-6|Quinine sulfate hydrate|FEMA No. 2977|Qualaquin|Quinine sulfate (2:1) (salt) dihydrate|KF7Z0E0Q2B|Quinine sulphate|DTXSID0048
Specifications & PurityBioReagent, for fluorescence analysis, ≥99%
Biochemical and Physiological MechanismsPotassium channel blocker. Antimalarial, anticholinergic, antihypertensive and hypoglycemic agent. Inhibits mitochondrial ATP-regulated potassium channel.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeBioReagent, for fluorescence analysis
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Associated Targets

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

INPPL1 Tchem Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

INPP5D Tbio Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid;dihydrate
INCHI InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
InChi Key ZHNFLHYOFXQIOW-LPYZJUEESA-N
Canonical SMILES COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
Isomeric SMILES COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.O.O.OS(=O)(=O)O
Alternate CAS 549-56-4
PubChem CID 16211610
Molecular Weight 782.95
Beilstein 6113937

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot NumberCertificate TypeDateItem
A2305625Certificate of AnalysisNov 25, 2022 Q110176
A2305646Certificate of AnalysisNov 25, 2022 Q110176
A2305681Certificate of AnalysisNov 25, 2022 Q110176
A2305687Certificate of AnalysisNov 25, 2022 Q110176
A2305725Certificate of AnalysisNov 25, 2022 Q110176
A2305819Certificate of AnalysisNov 25, 2022 Q110176
H2229518Certificate of AnalysisJul 21, 2022 Q110176
H2229519Certificate of AnalysisJul 21, 2022 Q110176
H2229520Certificate of AnalysisJul 21, 2022 Q110176
F2215138Certificate of AnalysisMar 03, 2021 Q110176
G2220405Certificate of AnalysisMar 03, 2021 Q110176

more

Chemical and Physical Properties

SolubilitySoluble in a mixture of chloroform and absolute alcohol (2:1).
SensitivityLight sensitive
Melt Point(°C)233-235°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

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References

1. 张长波.  (2022)  单激发双发射氮掺杂碳量子点的制备及其在生物成像和荧光油墨中的应用.  贵州师范大学学报( 自然科学版),  40  (4): (7-14).  [PMID:]

Solution Calculators

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